Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration

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Biological models for cardiac regeneration and remodeling, along with the effects of cytokines or chemokines during the therapy with mesenchymal stem cells after a myocardial infarction, are of crucial importance for understanding the complex underlying mechanisms. This paper presents a mathematical...

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Detalles Bibliográficos
Autores: Daniele Andreucci, Daniele, Bersani, Alberto, Bersani, Enrico, Caressa, Paolo, Dumett, Miguel, León Trujillo, Francisco James, Marconi, Silvia, Rubio, Obidio, Zarate-Pedrera, Yessica E.
Formato: artículo
Fecha de Publicación:2024
Institución:Universidad de Lima
Repositorio:ULIMA-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.ulima.edu.pe:20.500.12724/23218
Enlace del recurso:https://hdl.handle.net/20.500.12724/23218
https://doi.org/10.3390/math12131937
Nivel de acceso:acceso abierto
Materia:Pendiente
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spelling Daniele Andreucci, DanieleBersani, AlbertoBersani, EnricoCaressa, PaoloDumett, MiguelLeón Trujillo, Francisco JamesMarconi, SilviaRubio, ObidioZarate-Pedrera, Yessica E.León Trujillo, Francisco James2025-09-09T21:26:38Z2025-09-09T21:26:38Z20242227-7390https://hdl.handle.net/20.500.12724/23218Mathematics121541816WOS:001270010400001https://doi.org/10.3390/math121319372-s2.0-85198431436Biological models for cardiac regeneration and remodeling, along with the effects of cytokines or chemokines during the therapy with mesenchymal stem cells after a myocardial infarction, are of crucial importance for understanding the complex underlying mechanisms. This paper presents a mathematical model composed of three coupled partial differential equations that describes the dynamics of stem cells, nutrients and chemokines, highlighting the fundamental role of the chemokines during the myocardial tissue regeneration process. The system is solved numerically using mimetic difference operators and the MOLE library for MATLAB. The results show the tissue regeneration process in the necrotic part closest to the cell implantation area.Esta investigación fue realizada gracias al financiamiento otorgado por el Consejo Nacional de Ciencia, Tecnología e Innovación Tecnológica (CONCYTEC) a través del Programa Nacional de Investigación Científica y Estudios Avanzados - Prociencia, bajo el contrato N°: PE501078531-2022. https://hdl.handle.net/20.500.12724/21336application/htmlengMultidisciplinary Digital Publishing Institute (MDPI)CHurn:issn: 2227-7390info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/4.0/PendientePendienteSome Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regenerationinfo:eu-repo/semantics/articleArtículo (Scopus / Web of Science)reponame:ULIMA-Institucionalinstname:Universidad de Limainstacron:ULIMA20.500.12724/23218oai:repositorio.ulima.edu.pe:20.500.12724/232182025-11-08 09:06:38.959Repositorio Universidad de Limarepositorio@ulima.edu.pe
dc.title.en_EN.fl_str_mv Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
title Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
spellingShingle Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
Daniele Andreucci, Daniele
Pendiente
Pendiente
title_short Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
title_full Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
title_fullStr Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
title_full_unstemmed Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
title_sort Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
author Daniele Andreucci, Daniele
author_facet Daniele Andreucci, Daniele
Bersani, Alberto
Bersani, Enrico
Caressa, Paolo
Dumett, Miguel
León Trujillo, Francisco James
Marconi, Silvia
Rubio, Obidio
Zarate-Pedrera, Yessica E.
author_role author
author2 Bersani, Alberto
Bersani, Enrico
Caressa, Paolo
Dumett, Miguel
León Trujillo, Francisco James
Marconi, Silvia
Rubio, Obidio
Zarate-Pedrera, Yessica E.
author2_role author
author
author
author
author
author
author
author
dc.contributor.other.none.fl_str_mv León Trujillo, Francisco James
dc.contributor.author.fl_str_mv Daniele Andreucci, Daniele
Bersani, Alberto
Bersani, Enrico
Caressa, Paolo
Dumett, Miguel
León Trujillo, Francisco James
Marconi, Silvia
Rubio, Obidio
Zarate-Pedrera, Yessica E.
dc.subject.none.fl_str_mv Pendiente
topic Pendiente
Pendiente
dc.subject.ocde.none.fl_str_mv Pendiente
description Biological models for cardiac regeneration and remodeling, along with the effects of cytokines or chemokines during the therapy with mesenchymal stem cells after a myocardial infarction, are of crucial importance for understanding the complex underlying mechanisms. This paper presents a mathematical model composed of three coupled partial differential equations that describes the dynamics of stem cells, nutrients and chemokines, highlighting the fundamental role of the chemokines during the myocardial tissue regeneration process. The system is solved numerically using mimetic difference operators and the MOLE library for MATLAB. The results show the tissue regeneration process in the necrotic part closest to the cell implantation area.
publishDate 2024
dc.date.accessioned.none.fl_str_mv 2025-09-09T21:26:38Z
dc.date.available.none.fl_str_mv 2025-09-09T21:26:38Z
dc.date.issued.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.other.none.fl_str_mv Artículo (Scopus / Web of Science)
format article
dc.identifier.issn.none.fl_str_mv 2227-7390
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.12724/23218
dc.identifier.journal.none.fl_str_mv Mathematics
dc.identifier.isni.none.fl_str_mv 121541816
dc.identifier.wosid.none.fl_str_mv WOS:001270010400001
dc.identifier.doi.none.fl_str_mv https://doi.org/10.3390/math12131937
dc.identifier.scopusid.none.fl_str_mv 2-s2.0-85198431436
identifier_str_mv 2227-7390
Mathematics
121541816
WOS:001270010400001
2-s2.0-85198431436
url https://hdl.handle.net/20.500.12724/23218
https://doi.org/10.3390/math12131937
dc.language.iso.none.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv urn:issn: 2227-7390
dc.rights.*.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.*.fl_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/4.0/
dc.format.none.fl_str_mv application/html
dc.publisher.en_EN.fl_str_mv Multidisciplinary Digital Publishing Institute (MDPI)
dc.publisher.country.none.fl_str_mv CH
dc.source.none.fl_str_mv reponame:ULIMA-Institucional
instname:Universidad de Lima
instacron:ULIMA
instname_str Universidad de Lima
instacron_str ULIMA
institution ULIMA
reponame_str ULIMA-Institucional
collection ULIMA-Institucional
repository.name.fl_str_mv Repositorio Universidad de Lima
repository.mail.fl_str_mv repositorio@ulima.edu.pe
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score 13.881192
Some Numerical Results on Chemotactic Phenomena in Stem Cell Therapy for Cardiac Regeneration
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).

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