Hepatoprotective effect of Smallanthus sonchifolius (yacon) aqueous extract in an acetaminophen intoxication model

• Autores: Arnao-Salas, Acela Inés, Suárez-Cunza, Silvia, Trabucco-Ricaldi, Juan, Cisneros-Chinchay,, Ruth, Rodrigo, María Elena
• Formato: artículo
• Fecha de Publicación: 2012
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/871
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/871
• Nivel de acceso: acceso abierto
• Materia: Smallathus sonchifolius; plantas medicinales; extractos vegetales; marcadores biológicos; catalasa; superóxido dismutasa; acetaminofeno.; Smallanthus sonchifolius; plants/medicinal; plant extracts; biological markers; catalase; superoxide dismutase; acetaminophen.

Objectives: To determine in serum and erythrocytes the yacon leaves (EAY) aqueous extract hepatoprotective effect in a model of acetaminophen poisoning in rats. Design: Experimental, cross sectional. Institution: Biochemistry and Nutrition Research Center, Faculty of Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru. Biological material: Yacon leaves. Interventions: Five groups of female rats (n = 6) received orally for five days either saline (SF), EAY or silymarin (Sil) (50 mg/kg) and after 1 hour, SF or acetaminophen (A) 250 mg/kg, as follows: G1 (control; SF-SF), G2 (SF-A), G3 (EAY (200 mg/kg)-A), G4 (EAY (400 mg/kg)-A) and G5 (Sil-A). Main outcome measures: Aspartate amino transferase activity (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), and γ-glutamyltranspeptidase (γ-GTP); total bilirubin levels (BT), protein and lipid peroxidation (MDA). Superoxide dismutase (SOD), catalase (CAT) and hemoglobin activities in erythrocytes. Results: There was significant increase of γ-GTP activity (p <0.05) between group G2 and groups G3 and G4, and significant decrease (p <0.05) in proteins in group G2 in relation to group G1. MDA level was lower in the group receiving 200 mg/kg of EAY with respect to control. AST, ALT and FAL activities showed no significant differences. SOD/CAT ratio was similar between groups G1, G4 and G5, evidence of recovery from acetaminophen damage. Conclusions: EAY administration had hepatoprotective effect comparable to silymarin.