Biological and molecular characteristics of CD66c and its importance in the prognosis of acute lymphoblastic leukemia

• Autores: Bigoni Ordóñez, Gabriele, Mejía Buri , Julia Ximena
• Formato: artículo
• Fecha de Publicación: 2024
• Institución: Universidad de Huánuco
• Repositorio: Revistas - Universidad de Huánuco
• Lenguaje: español
• OAI Identifier: oai:ojs2.localhost:article/465
• Enlace del recurso: http://revistas.udh.edu.pe/index.php/RPCS/article/view/465
• Nivel de acceso: acceso abierto
• Materia: CD66c; pronóstico; leucemia; leucemia linfoblástica aguda de células precursoras B; prognosis; leukemia; precursor B-cell acute lymphoblastic leukemia

This study aims to gather information on the characteristics and functions of the CD66c moleculethrough a literature review, as well as its prognostic role when expressed in acute lymphoblasticleukemia (ALL). ALL is a disease originating from the malignant proliferation of hematopoietic cells. It is the most common cancer in the pediatric population, with a survival rate exceeding 70% globally in developed countries. In adult patients, the disease most frequently occurs between the ages of 20 and 40, with an unfavorable prognosis in this population. Several studies have demonstrated the presence of the glycoprotein CD66c in ALL, describing it as a potential marker related to genetic alterations such as BCR-ABL1, hyperdiploidy, and TEL-AML1 fusiongene negativity. CD66c is a member of the carcinoembryonic antigen (CEA) family, expressedin the granulocytic lineage, and is involved in functions such as cell adhesion, regulation of gene expression, migration, and signal transduction.