Efficacy and safety of lyophilized concentrate purple corn (Zea mays L.) in preventing the formation of colonic polyps

• Autores: Ichiyanagui R., Carlos, Soriano A., César, Frisancho V., Oscar
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Sociedad de Gastroenterología del Perú
• Repositorio: Revista de Gastroenterología del Perú
• Lenguaje: español
• OAI Identifier: oai:ojs.revistagastroperu.com:article/1308
• Enlace del recurso: http://www.revistagastroperu.com/index.php/rgp/article/view/1308
• Nivel de acceso: acceso abierto
• Materia: Chemoprevention; Colorectal cancer; Zea mays; Colonic polyps; Quimioprevención; Cáncer Colorrectal; Pólipos colónicos L.

Introduction: Colorectal cancer (CRC) is a worldwide problem of public health and arises mainly from polyps. In last 25 years, a strategy called chemoprevention that consists of food intake like purple corn and turmeric or chemical substances like acetyl salicylic acid (ASA) and non-steroidal anti-inflammatory drugs (NSAIDs) that prevent effectively carcinogenesis reducing the risk of polyp development. Objective: To determine the efficacy and safety of lyophilized concentrate of purple corn (Zea mays L.) 200 mg in the prevention of colonic polyps development in private gastroenterological practice Methods: we randomly assigned 112 patients (cases) to receive this product and 112 patients (controls) to receive placebo, during 3 years. Both groups had similar demographic, clinical and medical history characteristics. Results: we found that cases developed 83% less polyps than controls (p<0.001). The cases that developed polyps were smaller in number, size and histology than at the beginning of the trial. The adverse events that cases presented were 4.5% similar to controls, mainly petechiae. Conclusion: We conclude that the lyophilize 0 mg was effective and safe in preventing the development of colonic polyps.