Pharmacological interactions from the leaves of Maytenus macrocarpa "chuchuhuasi" with inhibitory and stimulating bowel motility drugs

• Autores: Meléndez-Espíritu , S., Huaccho-Rojas, J., Santos-Cajahuanca , F., Abanto-Cabeza , C., Jáuregui-Farfán , J., Mendoza-Toribio , J., Morales-Zenteno , E., Salgado-Silva , L., Sueyoshi-Hernández , H., Robles-Ojeda , M., Loja- Herrera , B., Alvarado-Yarasca, A., Salazar-Granara , A.
• Formato: artículo
• Fecha de Publicación: 2013
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:amp.cmp.org.pe:article/1341
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/1341
• Nivel de acceso: acceso abierto
• Materia: Interacciones de drogas; motilidad intestinal; sinergismo; antagonismo; medicina tradicional; plantas medicinales; Maytenus; loperamida; metoclopramida; Drug; Interactions; Gastrointestinal Motility; Synergism; Antagonism; Traditional Medicine; Medicinal Plant; Loperamide; Metoclopramide

Objectives: To determine the possible pharmacological interactions from the leaves of Maytenus macrocarpa with inhibitory and stimulating bowel motility drugs. Methods: We used 110 male albino mice with average weight of 25g, Arbos and others method was applied. Activated charcoal was administered at 5 % at dose of 0.1ml/10g, as an intestinal marker. The experimental groups included 0.1 ml/10 g of distilled water, leave extract of M. macrocarpa 1 (500mg/kg), leave extract of M. macrocarpa 2 (3000 mg/kg), 1,5mg/kg of atropine, 5mg/kg of loperamide, 0.4mg/kg of neostigmine, 10mg/kg of metoclopramide, leave extract of M. macrocarpa 1 with metoclopramide, leave extract of M. macrocarpa 1 with loperamide, leave extract of M. macrocarpa 2 with metoclopramide and leave extract of M. macrocarpa 2 with loperamide. The statistical validation was based on Wilconxon, ANOVA and Tukey test. Results: The intestinal charcoal run percentage was 27.04, 34.15, 31.66, 25.57, 15.89, 43.30, 33.99, 32.40, 27.9, 49.34 and 25.36 respectively. The ANOVA test result in p= 0.0007. The Tukey test indicated p <0.05 versus the control group for neostigmine, loperamide, and the interaction between leave extract of M. macrocarpa 2 with metoclopramide, for the last the Wilcoxon test result in p <0.05. Conclusions: It was observed antagonism drug interactions on gastrointestinal motility between leaves extract of M. macrocarpa with loperamide and synergism interactions with metoclopramide.