Effect of SARS-COV-2 on kidney tissue: a narrative review
Descripción del Articulo
We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney in...
| Autores: | , , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2021 |
| Institución: | Colegio Médico del Perú |
| Repositorio: | Acta Médica Peruana |
| Lenguaje: | español |
| OAI Identifier: | oai:ojs.pkp.sfu.ca:article/1885 |
| Enlace del recurso: | https://amp.cmp.org.pe/index.php/AMP/article/view/1885 |
| Nivel de acceso: | acceso abierto |
| Materia: | Histopathology Pathophysiology SARS-CoV-2 COVID-19 Acute Kidney Injury Kidney |
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Effect of SARS-COV-2 on kidney tissue: a narrative reviewSARS-CoV-2 y su efecto a nivel de tejido renal: Una revisión narrativaFlores Gavino, AldoEspinoza Anchaygua, RicardoHerrera Añazco, PercyRodriguez-Morales, Alfonso J.HistopathologyPathophysiologySARS-CoV-2COVID-19Acute Kidney InjuryKidneyWe describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin–Angiotensin–Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.Se describe la evidencia actual del efecto del SARS-CoV-2 a nivel de tejido renal. Se realizó una revisión narrativa de los artículos publicados en SCOPUS y PUBMED hasta septiembre de 2020. Los resultados se dividieron en las siguientes secciones: evidencia del efecto directo del virus en el riñón, mecanismos de invasión celular, mecanismos de injuria celular y las potenciales implicaciones terapéuticas de estos hallazgos. El SARS-CoV-2 invade las células del túbulo proximal y los podocitos, a través del receptor ECA-2. La invasión y replicación viral podrían producir daño mediante un efecto citopático directo aunado a un daño mediado por la respuesta inmune. Debido a la expresión celular de ECA-2, se ha propuesto a los Inhibidores del Sistema Renina–Angiotensina–Aldosterona como un potencial tratamiento contra la COVID-19. Sin embargo, a la fecha, la evidencia no apoya su usoColegio Médico del Perú2021-05-23info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://amp.cmp.org.pe/index.php/AMP/article/view/188510.35663/amp.2021.381.1885ACTA MEDICA PERUANA; Vol 38 No 1 (2021): January - March; 53-57ACTA MEDICA PERUANA; Vol. 38 Núm. 1 (2021): Enero - Marzo; 53-571728-59171018-8800reponame:Acta Médica Peruanainstname:Colegio Médico del Perúinstacron:CMPspahttps://amp.cmp.org.pe/index.php/AMP/article/view/1885/1277Copyright (c) 2021 ACTA MEDICA PERUANAinfo:eu-repo/semantics/openAccessoai:ojs.pkp.sfu.ca:article/18852023-10-06T07:13:09Z |
| dc.title.none.fl_str_mv |
Effect of SARS-COV-2 on kidney tissue: a narrative review SARS-CoV-2 y su efecto a nivel de tejido renal: Una revisión narrativa |
| title |
Effect of SARS-COV-2 on kidney tissue: a narrative review |
| spellingShingle |
Effect of SARS-COV-2 on kidney tissue: a narrative review Flores Gavino, Aldo Histopathology Pathophysiology SARS-CoV-2 COVID-19 Acute Kidney Injury Kidney |
| title_short |
Effect of SARS-COV-2 on kidney tissue: a narrative review |
| title_full |
Effect of SARS-COV-2 on kidney tissue: a narrative review |
| title_fullStr |
Effect of SARS-COV-2 on kidney tissue: a narrative review |
| title_full_unstemmed |
Effect of SARS-COV-2 on kidney tissue: a narrative review |
| title_sort |
Effect of SARS-COV-2 on kidney tissue: a narrative review |
| dc.creator.none.fl_str_mv |
Flores Gavino, Aldo Espinoza Anchaygua, Ricardo Herrera Añazco, Percy Rodriguez-Morales, Alfonso J. |
| author |
Flores Gavino, Aldo |
| author_facet |
Flores Gavino, Aldo Espinoza Anchaygua, Ricardo Herrera Añazco, Percy Rodriguez-Morales, Alfonso J. |
| author_role |
author |
| author2 |
Espinoza Anchaygua, Ricardo Herrera Añazco, Percy Rodriguez-Morales, Alfonso J. |
| author2_role |
author author author |
| dc.subject.none.fl_str_mv |
Histopathology Pathophysiology SARS-CoV-2 COVID-19 Acute Kidney Injury Kidney |
| topic |
Histopathology Pathophysiology SARS-CoV-2 COVID-19 Acute Kidney Injury Kidney |
| description |
We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications. SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin–Angiotensin–Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-05-23 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://amp.cmp.org.pe/index.php/AMP/article/view/1885 10.35663/amp.2021.381.1885 |
| url |
https://amp.cmp.org.pe/index.php/AMP/article/view/1885 |
| identifier_str_mv |
10.35663/amp.2021.381.1885 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://amp.cmp.org.pe/index.php/AMP/article/view/1885/1277 |
| dc.rights.none.fl_str_mv |
Copyright (c) 2021 ACTA MEDICA PERUANA info:eu-repo/semantics/openAccess |
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Copyright (c) 2021 ACTA MEDICA PERUANA |
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openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Colegio Médico del Perú |
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Colegio Médico del Perú |
| dc.source.none.fl_str_mv |
ACTA MEDICA PERUANA; Vol 38 No 1 (2021): January - March; 53-57 ACTA MEDICA PERUANA; Vol. 38 Núm. 1 (2021): Enero - Marzo; 53-57 1728-5917 1018-8800 reponame:Acta Médica Peruana instname:Colegio Médico del Perú instacron:CMP |
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Colegio Médico del Perú |
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CMP |
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CMP |
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Acta Médica Peruana |
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Acta Médica Peruana |
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Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
