Effect of SARS-COV-2 on kidney tissue: a narrative review

• Autores: Flores Gavino, Aldo, Espinoza Anchaygua, Ricardo, Herrera Añazco, Percy, Rodriguez-Morales, Alfonso J.
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:ojs.pkp.sfu.ca:article/1885
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/1885
• Nivel de acceso: acceso abierto
• Materia: Histopathology; Pathophysiology; SARS-CoV-2; COVID-19; Acute Kidney Injury; Kidney

We describe evidence on SARS-CoV-2 effect on the kidney. We carried a narrative review of articles published in SCOPUS and PUBMED until September 2020. The results were divided into six topics: evidence of direct effect of virus on the kidney, mechanisms of cellular invasion, mechanisms of kidney injury, and potential therapeutic implications.  SARS-Cov-2 gains access to proximal tubule cells and podocytes via ACE-2 receptors. Viral invasion and replication may induce kidney damage through a direct cytopathic effect and immune-mediated damage. Due to ACE-2 cellular expression, Renin–Angiotensin–Aldosterone System Inhibitors have been proposed as potential treatment for COVID-19. However, current evidence does not support its therapeutic use.