Update on the epidemiology of carbapenemases in Latin America and the Caribbean

• Autores: García-Betancur, JC, Appel, TM, Esparza, G, Gales, AC, Levy-Hara, G, Cornistein, W, Vega, S, Nuñez, D, Cuellar, L, Bavestrello, A, Castañeda-Méndez, F, Villalobos-Vindas, JM, Villegas, MV
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Instituto Nacional de Enfermedades Neoplásicas
• Repositorio: INEN-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.inen.sld.pe:inen/91
• Enlace del recurso: https://repositorio.inen.sld.pe/handle/inen/91
• Nivel de acceso: acceso abierto
• Materia: Acinetobacter baumannii; Klebsiella pneumoniae; Pseudomonas aeruginosa; Latin America; carbapenem resistance; carbapenem-resistant Enterobacterales (CRE); carbapenemases; carbapenems.; https://purl.org/pe-repo/ocde/ford#3.02.21

Introduction: Carbapenemases are β-lactamases able to hydrolyze a wide range of β-lactam antibiotics, including carbapenems. Carbapenemase production in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp., with and without the co-expression of other β-lactamases is a serious public health threat. Carbapenemases belong to three main classes according to the Ambler classification: class A, class B, and class D. Areas covered: Carbapenemase-bearing pathogens are endemic in Latin America. In this review, we update the status of carbapenemases in Latin America and the Caribbean.Expert opinion: Understanding the current epidemiology of carbapenemases in Latin America and the Caribbean is of critical importance to improve infection control policies limiting the dissemination of multi-drug-resistant pathogens and in implementing appropriate antimicrobial therapy.