Antimicrobial resistance is one of the greatest threats to public health, and hospital wastewater effluents are an important source of transmission for resistant pathogens. The objective of this study was to determine the presence of multidrug-resistant bacteria producing extended-spectrum beta-lactamases, AmpC, and carbapenemases in hospital effluents from three regions of Peru. Bacteria were collected and characterized from nine hospitals using chromogenic media and an automated microbiology system. Conventional PCR was also used to identify resistance genes for beta-lactamases, such as blaCTX-M, blaTEM, blaSHV, blaAmpC, and carbapenemases like KPC, NDM, and IMP. Fifty-five isolates were identified from various healthcare centers, with extended-spectrum beta-lactamase genes, such as blaTEM, found. In level II2 hospitals, the KPC resistance gene was found, particularly in the Regional H...

About IMMUNOPERU 2025: This IUIS-ALACI-PSI course has brought together a diverse group of students, immunologists and experts to share their distinct perspectives, skills and expertise. The focus was on a variety of endemic and emerging diseases related to environmental and climate change. The goal was to catalyze the development of novel concepts, methods and approaches in addressing these emerging challenges. MAIN TOPICS: The course has addressed the Impact of environmental exposures on immunity in infectious disease, chronic inflammation and cancer with particular attention to: Changes in microbial communities and their metabolites that drive inflammatory disease (eg. effects of antibiotics, dietary and other factors) Environmental cues and pollutants linked to the development of hematologic malignancies. The impact of climate change on endemic infectious diseases (eg. Tuberculosis, D...

Plasmodium falciparum en la Amazonía de Perú se ha descrito en años recientes como una población clonal, presentándose en casos de infecciones monoclonales, y que los parásitos que actualmente circulan serían producto de un reemplazo clonal. Adicionalmente, la frecuencia de los parásitos portadores de la deleción de los genes pfhrp2 y pfhrp3 ha aumentado, predominando en la población de P. falciparum. Por otro lado, no se conoce que factores genéticos podrían subyacer a la persistencia de las infecciones por P. falciparum y al incremento en el tiempo de los parásitos con la deleción de los genes pfhrp2/3. Por ello, el objetivo principal del presente estudio fue identificar regiones genómicas de P. falciparum que muestren evidencia de selección positiva reciente para esta especie; y de manera específica, en el grupo de parásitos con la deleción de los genes pfhrp2 y pfh...