The objective of this research work is to specify that the APOE methodology, the Van Hiele method and the use of the GeoGebra software, combined, should enhance the teaching-learning strategies, facilitating the work of both the teacher and the student. Everything is concentrated in example 2 on page 56, synthesizing, asking for the parametric and symmetric equations of the line that passes through two points A and B located in three-dimensional space, in part b) find the point of intersection of said straight line with plane x y, the latter has a high degree of complexity, the tools that a student must have to face this type of exercises are, obviously, intermediate level algebra as well as the use of trigonometry. Next, I will synthesize the procedures, this will serve as a roadmap which will make explicit what has been worked. First: we obtained the vector equation of the line. Second...

Aquatic ecosystems are under continuous pressure from industrial, agricultural, and urban contaminants that form complex mixtures, making their evaluation highly challenging. Traditional chemical analyses perform an essential role but fail to accurately represent the real impact of these substances on biota. In this context, the bioecotoximonitor—defined as a fish with physiological and behavioral sensitivity to pollutants and associated with an indicator organism represents an innovation in aquatic ecotoxicology. The proposal focuses on a service-oriented technology that provides standardized environmental monitoring bioassays. This service includes breeding and maintenance protocols, exposure tests under laboratory or field conditions, recording of physiological and behavioral variables, and the issuance of reports with scientific and regulatory value. The main strength of the bioeco...

La proteína priónica (PrP) es patogénica cuando está anormalmente plegada, causando las llamadas “encefalopatías espongiformes transmisibles”. Además, la evidencia reciente indica que PrP media la muerte neuronal en el mal de Alzheimer. Sin embargo, se sabe muy poco sobre los complejos roles fisiológicos que cumple en su estado natural, haciendo necesario elucidar su contribución a los mecanismos moleculares que subyacen la neurodegeneración. Los embriones de pez cebra (Danio rerio) tienen muchas ventajas como modelo animal: su desarrollo es externo y rápido, son transparentes, se puede obtener muchos de ellos de una sola cruza y poseen alta homología genética y similitudes fisiológicas con humanos. El pez cebra expresa dos proteínas ortólogas de la PrP mamífera: PrP-1, mediando adhesión celular ubicuamente en blástula y gástrula, y PrP-2 que es más parecida a la ...