Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors

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kocfachung@gmail.com
Detalles Bibliográficos
Autores: Chung Delgado, Kocfa, Guillen Bravo, Sonia, Revilla Montag, Alejandro, Bernabe-Ortiz, Antonio
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/344468
Enlace del recurso:http://hdl.handle.net/10757/344468
Nivel de acceso:acceso abierto
Materia:Tuberculosis
Mortalidad
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dc.title.es_PE.fl_str_mv Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
dc.title.alternative.es_PE.fl_str_mv Tuberculosis sensible y drogorresistente: Mortalidad y sus factores asociados
title Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
spellingShingle Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
Chung Delgado, Kocfa
Tuberculosis
Mortalidad
title_short Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
title_full Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
title_fullStr Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
title_full_unstemmed Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
title_sort Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
author Chung Delgado, Kocfa
author_facet Chung Delgado, Kocfa
Guillen Bravo, Sonia
Revilla Montag, Alejandro
Bernabe-Ortiz, Antonio
author_role author
author2 Guillen Bravo, Sonia
Revilla Montag, Alejandro
Bernabe-Ortiz, Antonio
author2_role author
author
author
dc.contributor.author.fl_str_mv Chung Delgado, Kocfa
Guillen Bravo, Sonia
Revilla Montag, Alejandro
Bernabe-Ortiz, Antonio
dc.subject.es_PE.fl_str_mv Tuberculosis
Mortalidad
topic Tuberculosis
Mortalidad
description kocfachung@gmail.com
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2015-02-14T15:02:23Z
dc.date.available.es_PE.fl_str_mv 2015-02-14T15:02:23Z
dc.date.issued.fl_str_mv 2015-02-14
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.es_PE.fl_str_mv 10.1371/journal.pone.0119332
1. Chung-Delgado K, Guillen-Bravo S, Revilla-Montag A, Bernabe-Ortiz A. Mortality among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors. Caylà JA, editor. PLoS One [Internet]. 2015 Mar 19 [cited 2017 Jun 12];10(3):e0119332. Available from: http://dx.plos.org/10.1371/journal.pone.0119332
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/344468
dc.identifier.eissn.es_PE.fl_str_mv 1932-6203
dc.identifier.journal.es_PE.fl_str_mv PLoS ONE
identifier_str_mv 10.1371/journal.pone.0119332
1. Chung-Delgado K, Guillen-Bravo S, Revilla-Montag A, Bernabe-Ortiz A. Mortality among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors. Caylà JA, editor. PLoS One [Internet]. 2015 Mar 19 [cited 2017 Jun 12];10(3):e0119332. Available from: http://dx.plos.org/10.1371/journal.pone.0119332
1932-6203
PLoS ONE
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spelling Chung Delgado, KocfaGuillen Bravo, SoniaRevilla Montag, AlejandroBernabe-Ortiz, Antonio2015-02-14T15:02:23Z2015-02-14T15:02:23Z2015-02-1410.1371/journal.pone.01193321. Chung-Delgado K, Guillen-Bravo S, Revilla-Montag A, Bernabe-Ortiz A. Mortality among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors. Caylà JA, editor. PLoS One [Internet]. 2015 Mar 19 [cited 2017 Jun 12];10(3):e0119332. Available from: http://dx.plos.org/10.1371/journal.pone.0119332http://hdl.handle.net/10757/3444681932-6203PLoS ONEkocfachung@gmail.comsoniaguillenb@gmail.comarmrons@gmail.comArtículo de revista que fue aceptada para publicación en la Revista PLOS ONE el 03 de Febrero de 2015.Background: An increase in multidrug-resistant tuberculosis (MDR-TB) cases is evident worldwide. Its management implies a complex treatment, high costs, more toxic anti-tuberculosis drug use, longer treatment time and increased treatment failure and mortality. The aims of this study were to compare mortality between MDR and drug-susceptible cases of tuberculosis, and to determine risk factors associated with mortality among MDR-TB cases. Methods and Results: A retrospective cohort study was performed using data from clinical records of the National Strategy for Prevention and Control of Tuberculosis in Lima, Peru. In the first objective, MDR-TB, compared to drug-susceptible cases, was the main exposure variable and time to death, censored at 180 days, the outcome of interest. For the second objective, different variables obtained from clinical records were assessed as potential risk factors for death among MDR-TB cases. Cox regression analysis was used to determine hazard ratios (HR) and 95% confidence intervals (95%CI). A total of 1,232 patients were analyzed: mean age 30.9 ±14.0 years, 60.0% were males. 61 patients (5.0%) died during treatment, whereas the MDR-TB prevalence was 19.2%. MDR-TB increased the risk of death during treatment (HR=7.5; IC95%: 4.1–13.4) when compared to presumed drug-susceptible cases after controlling for potential confounders. Education level (p=0.01), previous TB episodes (p<0.001), diabetes history (p<0.001) and HIV infection (p=0.04) were factors associated with mortality among MDR-TB cases. Conclusions: MDR-TB is associated with an increased risk of death during treatment. Lower education, greater number of previous TB episodes, diabetes history, and HIV infection were independently associated with mortality among MDR-TB cases. New strategies for appropriate MDR-TB detection and management should be implemented, including drug sensitivity tests, diabetes and HIV screening, as well as guarantee for a complete adherence to therapy.application/pdfengPLoS ONEinfo:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCTuberculosisMortalidadMortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated FactorsTuberculosis sensible y drogorresistente: Mortalidad y sus factores asociadosinfo:eu-repo/semantics/article2018-06-16T13:19:47ZBackground: An increase in multidrug-resistant tuberculosis (MDR-TB) cases is evident worldwide. Its management implies a complex treatment, high costs, more toxic anti-tuberculosis drug use, longer treatment time and increased treatment failure and mortality. The aims of this study were to compare mortality between MDR and drug-susceptible cases of tuberculosis, and to determine risk factors associated with mortality among MDR-TB cases. Methods and Results: A retrospective cohort study was performed using data from clinical records of the National Strategy for Prevention and Control of Tuberculosis in Lima, Peru. In the first objective, MDR-TB, compared to drug-susceptible cases, was the main exposure variable and time to death, censored at 180 days, the outcome of interest. For the second objective, different variables obtained from clinical records were assessed as potential risk factors for death among MDR-TB cases. Cox regression analysis was used to determine hazard ratios (HR) and 95% confidence intervals (95%CI). A total of 1,232 patients were analyzed: mean age 30.9 ±14.0 years, 60.0% were males. 61 patients (5.0%) died during treatment, whereas the MDR-TB prevalence was 19.2%. MDR-TB increased the risk of death during treatment (HR=7.5; IC95%: 4.1–13.4) when compared to presumed drug-susceptible cases after controlling for potential confounders. Education level (p=0.01), previous TB episodes (p<0.001), diabetes history (p<0.001) and HIV infection (p=0.04) were factors associated with mortality among MDR-TB cases. Conclusions: MDR-TB is associated with an increased risk of death during treatment. Lower education, greater number of previous TB episodes, diabetes history, and HIV infection were independently associated with mortality among MDR-TB cases. 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score 13.754616
Mortality Among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors
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