Multinational prospective cohort study of rates and risk factors for ventilator-associated pneumonia over 24 years in 42 countries of Asia, Africa, Eastern Europe, Latin America, and the Middle East: Findings of the International Nosocomial Infection Control Consortium (INICC)

• Autores: Rosenthal, Victor Daniel, Jin, Zhilin, Memish, Ziad A., Rodrigues, Camilla, Myatra, Sheila Nainan, Kharbanda, Mohit, Valderrama-Beltran, Sandra Liliana, Mehta, Yatin, Daboor, Mohammad Abdellatif, Todi, Subhash Kumar, Aguirre-Avalos, Guadalupe, Guclu, Ertugrul, Gan, Chin Seng, Jiménez Alvarez, Luisa Fernanda, Chawla, Rajesh, Hlinkova, Sona, Arjun, Rajalakshmi, Agha, Hala Mounir, Zuniga Chavarria, Maria Adelia, Davaadagva, Narangarav, Mohd Basri, Mat Nor, Gomez, Katherine, Aguilar De Moros, Daisy, Tai, Chian Wern, Sassoe Gonzalez, Alejandro, Aguilar Moreno, Lina Alejandra, Sandhu, Kavita, Janc, Jarosław, Aleman Bocanegra, Mary Cruz, Yildizdas, Dincer, Cano Medina, Yuliana Andrea, Villegas Mota, Maria Isabel, Omar, Abeer Aly, Duszynska, Wieslawa, Belkebir, Souad, El-Kholy, Amani Ali, Abdulaziz Alkhawaja, Safaa, Horhat Florin, George, Medeiros, Eduardo Alexandrino, Tao, Lili, Tumu, Nellie, Elanbya, May Gamar, Dongol, Reshma, Mioljević, Vesna, Raka, Lul, Dueñas, Lourdes, Carreazo, Nilton Yhuri, Dendane, Tarek, Ikram, Aamer, Kanj, Souha S., Petrov, Michael M., Bouziri, Asma, Hung, Nguyen Viet, Belskiy, Vladislav, Elahi, Naheed, Bovera, María Marcela, Yin, Ruijie
• Formato: artículo
• Fecha de Publicación: 2023
• Institución: Universidad Peruana de Ciencias Aplicadas
• Repositorio: UPC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorioacademico.upc.edu.pe:10757/668158
• Enlace del recurso: http://hdl.handle.net/10757/668158
• Nivel de acceso: acceso abierto
• Materia: Ventilator-associated pneumonia (VAP; Low- and middle-income countries (LMIC); Intensive Care Units (ICUs); Risk factors; Prospective cohort study; Male sex; Length of stay (LOS); Mechanical ventilation (MV); Continuous Positive Airway Pressure (CPAP); Multivariate logistic regression

Objective: Rates of ventilator-associated pneumonia (VAP) in low- and middle-income countries (LMIC) are several times above those of high-income countries. The objective of this study was to identify risk factors (RFs) for VAP cases in ICUs of LMICs. Design: Prospective cohort study. Setting: This study was conducted across 743 ICUs of 282 hospitals in 144 cities in 42 Asian, African, European, Latin American, and Middle Eastern countries. Participants: The study included patients admitted to ICUs across 24 years. Results: In total, 289,643 patients were followed during 1,951,405 patient days and acquired 8,236 VAPs. We analyzed 10 independent variables. Multiple logistic regression identified the following independent VAP RFs: male sex (adjusted odds ratio [aOR], 1.22; 95% confidence interval [CI], 1.16-1.28; P <.0001); longer length of stay (LOS), which increased the risk 7% per day (aOR, 1.07; 95% CI, 1.07-1.08; P <.0001); mechanical ventilation (MV) utilization ratio (aOR, 1.27; 95% CI, 1.23-1.31; P <.0001); continuous positive airway pressure (CPAP), which was associated with the highest risk (aOR, 13.38; 95% CI, 11.57-15.48; P <.0001)