An unidentified cluster of infection in the Peruvian Amazon region

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joruiz@clinic.ub.es
Detalles Bibliográficos
Autores: Cornejo Tapia, Ángela, Gomes, Cláudia, Suárez Ognio, Luis, Martínez Puchol, Sandra, Bustamante, Pershing, Pons, Maria J., Ruiz, Joaquim, Del Valle Mendoza, Juana
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/555445
Enlace del recurso:http://hdl.handle.net/10757/555445
Nivel de acceso:acceso abierto
Materia:Bartonella spp.
Sphingomonas; diagnosis
Outbreak
Perú
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dc.title.es_PE.fl_str_mv An unidentified cluster of infection in the Peruvian Amazon region
title An unidentified cluster of infection in the Peruvian Amazon region
spellingShingle An unidentified cluster of infection in the Peruvian Amazon region
Cornejo Tapia, Ángela
Bartonella spp.
Sphingomonas; diagnosis
Outbreak
Perú
title_short An unidentified cluster of infection in the Peruvian Amazon region
title_full An unidentified cluster of infection in the Peruvian Amazon region
title_fullStr An unidentified cluster of infection in the Peruvian Amazon region
title_full_unstemmed An unidentified cluster of infection in the Peruvian Amazon region
title_sort An unidentified cluster of infection in the Peruvian Amazon region
author Cornejo Tapia, Ángela
author_facet Cornejo Tapia, Ángela
Gomes, Cláudia
Suárez Ognio, Luis
Martínez Puchol, Sandra
Bustamante, Pershing
Pons, Maria J.
Ruiz, Joaquim
Del Valle Mendoza, Juana
author_role author
author2 Gomes, Cláudia
Suárez Ognio, Luis
Martínez Puchol, Sandra
Bustamante, Pershing
Pons, Maria J.
Ruiz, Joaquim
Del Valle Mendoza, Juana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cornejo Tapia, Ángela
Gomes, Cláudia
Suárez Ognio, Luis
Martínez Puchol, Sandra
Bustamante, Pershing
Pons, Maria J.
Ruiz, Joaquim
Del Valle Mendoza, Juana
dc.subject.es_PE.fl_str_mv Bartonella spp.
Sphingomonas; diagnosis
Outbreak
Perú
topic Bartonella spp.
Sphingomonas; diagnosis
Outbreak
Perú
description joruiz@clinic.ub.es
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2015-05-21T17:53:46Z
dc.date.available.es_PE.fl_str_mv 2015-05-21T17:53:46Z
dc.date.issued.fl_str_mv 2015-05-21
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.es_PE.fl_str_mv 1972-2680
dc.identifier.doi.es_PE.fl_str_mv 10.3855/jidc.6235
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/555445
dc.identifier.journal.es_PE.fl_str_mv The Journal of Infection in Developing Countries (J Infect Dev Ctries.)
identifier_str_mv 1972-2680
10.3855/jidc.6235
The Journal of Infection in Developing Countries (J Infect Dev Ctries.)
url http://hdl.handle.net/10757/555445
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.jidc.org/index.php/journal/article/view/25989173/1306
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dc.publisher.es_PE.fl_str_mv The Journal of Infection in Developing Countries
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
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instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
reponame_str UPC-Institucional
collection UPC-Institucional
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spelling Cornejo Tapia, ÁngelaGomes, CláudiaSuárez Ognio, LuisMartínez Puchol, SandraBustamante, PershingPons, Maria J.Ruiz, JoaquimDel Valle Mendoza, Juana2015-05-21T17:53:46Z2015-05-21T17:53:46Z2015-05-211972-268010.3855/jidc.6235http://hdl.handle.net/10757/555445The Journal of Infection in Developing Countries (J Infect Dev Ctries.)joruiz@clinic.ub.esIntroduction: Bartonella bacilliformis is the etiological agent of Carrion’s disease, which is a neglected disease linked to people in low-socioeconomic populations in Andean valleys. An outbreak of B. bacilliformis was reported in a rural area of the Peruvian Amazon region. The aim of this study was to characterize this outbreak using molecular techniques. Methodology: Fifty-three blood samples from patients diagnosed with Carrion’s disease were analyzed by molecular tools, using both a Bartonella-specific polymerase chain reaction (PCR) and an universal PCR, both based on 16S rRNA gene amplification. Additional water samples from the area were also analyzed. Results: Unexpectedly, the samples were positive only when the universal PCR was used. Although environmental contamination cannot be ruled out, the results showed that Sphingomonas faeni was the possible causative agent of this outbreak, and that water was the most feasible infection source. Conclusions: Diagnosis by clinical criteria or microscopy may lead to misdiagnosis. There is a need to include molecular tools in the routine diagnosis of febrile syndromes, including Carrion’s disease.This study was funded by the Instituto de Salud Carlos III (ISCIII, Spain) (grant number: FI12/00561, which included FEDER funds), by the Spanish Network for the Research in Infectious Diseases (REIPI RD12/0015) and Generalitat de Catalunya, Departament d’Universitats, Recerca i Societat de la Informació (2014 SGR 26) (JR) and by internal funds of the Universidad Peruana de Ciencias Aplicadas (UPC), Lima-Peru (JdV). JR has a fellowship from the program I3, of the ISCIII (grant number: CES11/012). CG has a PhD fellowship of the ISCIII (FI12/00561). MJP has a postdoctoral fellowship from CONCYTEC. We thank Donna Pringle for language and idiomatic corrections.Revisión por paresapplication/pdfengThe Journal of Infection in Developing Countrieshttp://www.jidc.org/index.php/journal/article/view/25989173/1306info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCBartonella spp.90f7edae-2de1-4b53-b967-825133e974d4600Sphingomonas; diagnosise2e7e8f6-f9da-4fc0-a930-14c56d09ff6b600Outbreak8d3a1582-51d7-446e-b685-682ef58b66c5600Perú3ef1f6c8-106f-4187-ac39-34c1ab530fb7600An unidentified cluster of infection in the Peruvian Amazon regioninfo:eu-repo/semantics/article2018-06-17T09:14:29ZIntroduction: Bartonella bacilliformis is the etiological agent of Carrion’s disease, which is a neglected disease linked to people in low-socioeconomic populations in Andean valleys. An outbreak of B. bacilliformis was reported in a rural area of the Peruvian Amazon region. The aim of this study was to characterize this outbreak using molecular techniques. Methodology: Fifty-three blood samples from patients diagnosed with Carrion’s disease were analyzed by molecular tools, using both a Bartonella-specific polymerase chain reaction (PCR) and an universal PCR, both based on 16S rRNA gene amplification. Additional water samples from the area were also analyzed. Results: Unexpectedly, the samples were positive only when the universal PCR was used. Although environmental contamination cannot be ruled out, the results showed that Sphingomonas faeni was the possible causative agent of this outbreak, and that water was the most feasible infection source. Conclusions: Diagnosis by clinical criteria or microscopy may lead to misdiagnosis. 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An unidentified cluster of infection in the Peruvian Amazon region
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