Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
Descripción del Articulo
Presentación de Poster realizada durante el "The 16th International Congress on Infectios Diseases ICID". 2-4 April 2014, Cape Town, South Africa
| Autores: | , , , , , , , |
|---|---|
| Formato: | objeto de conferencia |
| Fecha de Publicación: | 2014 |
| Institución: | Universidad Peruana de Ciencias Aplicadas |
| Repositorio: | UPC-Institucional |
| Lenguaje: | inglés |
| OAI Identifier: | oai:repositorioacademico.upc.edu.pe:10757/332085 |
| Enlace del recurso: | https://doi.org/10.1016/j.ijid.2014.03.924 http://hdl.handle.net/10757/332085 |
| Nivel de acceso: | acceso abierto |
| Materia: | https://purl.org/pe-repo/ocde/ford#3.00.00 |
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Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department |
| title |
Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department |
| spellingShingle |
Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department Cornejo Tapia, Ángela https://purl.org/pe-repo/ocde/ford#3.00.00 |
| title_short |
Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department |
| title_full |
Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department |
| title_fullStr |
Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department |
| title_full_unstemmed |
Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department |
| title_sort |
Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department |
| author |
Cornejo Tapia, Ángela |
| author_facet |
Cornejo Tapia, Ángela Casabona, V. Gomes, C. S. P. Tinco, C. Martinez Puchol, S. Ruiz, J. Del Valle Mendoza, Juana Suárez Ognio, Luis |
| author_role |
author |
| author2 |
Casabona, V. Gomes, C. S. P. Tinco, C. Martinez Puchol, S. Ruiz, J. Del Valle Mendoza, Juana Suárez Ognio, Luis |
| author2_role |
author author author author author author author |
| dc.contributor.author.fl_str_mv |
Cornejo Tapia, Ángela Casabona, V. Gomes, C. S. P. Tinco, C. Martinez Puchol, S. Ruiz, J. Del Valle Mendoza, Juana Suárez Ognio, Luis |
| dc.subject.ocde.es_PE.fl_str_mv |
https://purl.org/pe-repo/ocde/ford#3.00.00 |
| topic |
https://purl.org/pe-repo/ocde/ford#3.00.00 |
| description |
Presentación de Poster realizada durante el "The 16th International Congress on Infectios Diseases ICID". 2-4 April 2014, Cape Town, South Africa |
| publishDate |
2014 |
| dc.date.accessioned.es_PE.fl_str_mv |
2014-10-04T01:55:38Z |
| dc.date.available.es_PE.fl_str_mv |
2014-10-04T01:55:38Z |
| dc.date.issued.fl_str_mv |
2014-10-03 |
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info:eu-repo/semantics/conferenceObject |
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| dc.identifier.doi.es_PE.fl_str_mv |
https://doi.org/10.1016/j.ijid.2014.03.924 |
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http://hdl.handle.net/10757/332085 |
| dc.identifier.journal.es_PE.fl_str_mv |
International Journal of Infectious Diseases |
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https://doi.org/10.1016/j.ijid.2014.03.924 http://hdl.handle.net/10757/332085 |
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International Journal of Infectious Diseases |
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eng |
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eng |
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http://www.sciencedirect.com/science/article/pii/S1201971214009837# |
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application/pdf |
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International Society for Infectious Diseases |
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Universidad Peruana de Ciencias Aplicadas (UPC) Repositorio Académico - UPC |
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virtual::1807-1Cornejo Tapia, ÁngelaCasabona, V.Gomes, C. S. P.Tinco, C.Martinez Puchol, S.Ruiz, J.Del Valle Mendoza, JuanaSuárez Ognio, Luis2014-10-04T01:55:38Z2014-10-04T01:55:38Z2014-10-03https://doi.org/10.1016/j.ijid.2014.03.924http://hdl.handle.net/10757/332085International Journal of Infectious DiseasesPresentación de Poster realizada durante el "The 16th International Congress on Infectios Diseases ICID". 2-4 April 2014, Cape Town, South AfricaBackground: In March 2013, the presence of an outbreak of Bartonella bacilliformis in the Rodriguez de Mendoza (Amazonas department, Peru) was reported. B. bacilliformis is an endemic pathogen of the Andean region, responsible for Carrion’s disease. One of the main problems of this illness is the lack of adequate technical and human resources for proper diagnosis in endemic rural areas. The objective of this study was to characterize a supposed B. bacilliformis outbreak, internationally informed in Rodriguez de Mendoza province. Methods & Materials: Fifty-three blood samples were recovered from people diagnosed with Carrion's disease, either by optical microscopy and/or clinical manifestations. In all cases epidemiological and clinical data were recorded. The samples were cultured on Columbia Agar adding 10% of sheep blood and incubated at 28°C for a period of 10 weeks. Every 14 days the plates were visually inspected to detect any bacterial growth. Additionally, the DNA was directly extracted from blood and 2 different 16S rRNA PCR schemes were used, one specific for Bartonella genus and other using universal primers. Twenty-six amplified products of universal 16S rRNA were randomly recovered and sequenced. Results: The main clinical presentations reported were headache (51%), physical discomfort (51%), chill (32%) and fever (24, 5%). Only 3 blood cultures were positive. No positive PCR was obtained when using the Bartonella specific PCR either on blood or on cultured bacteria. However, all the PCR with the universal primers were positive. The sequenced 26 (49%) samples were identified as Sphingomonas spp. being this microorganism the causative agent of this outbreak. In 17% of the cases, patients were reported to have aquatic activities. Conclusion: Several Sphingomonas spp. infections in humans have been reported, mostly limited to sporadic case reports or intra-hospitalary outbreaks, but as far as we know this is the first outbreak of Sphingomonas spp. described in a non-hospital environment. The association between 17% of patients with aquatic activities suggests that this was the most feasible transmission way.Training of health staff and development of new diagnostic able to be implemented in rural endemic areas is urgent in order to overcome wrong diagnostics and avoid wrong treatments.Revisión por paresapplication/pdfengInternational Society for Infectious Diseaseshttp://www.sciencedirect.com/science/article/pii/S1201971214009837#info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCMisdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon departmentinfo:eu-repo/semantics/conferenceObjecthttps://purl.org/pe-repo/ocde/ford#3.00.002018-06-16T09:19:39ZBackground: In March 2013, the presence of an outbreak of Bartonella bacilliformis in the Rodriguez de Mendoza (Amazonas department, Peru) was reported. B. bacilliformis is an endemic pathogen of the Andean region, responsible for Carrion’s disease. One of the main problems of this illness is the lack of adequate technical and human resources for proper diagnosis in endemic rural areas. The objective of this study was to characterize a supposed B. bacilliformis outbreak, internationally informed in Rodriguez de Mendoza province. Methods & Materials: Fifty-three blood samples were recovered from people diagnosed with Carrion's disease, either by optical microscopy and/or clinical manifestations. In all cases epidemiological and clinical data were recorded. The samples were cultured on Columbia Agar adding 10% of sheep blood and incubated at 28°C for a period of 10 weeks. Every 14 days the plates were visually inspected to detect any bacterial growth. Additionally, the DNA was directly extracted from blood and 2 different 16S rRNA PCR schemes were used, one specific for Bartonella genus and other using universal primers. Twenty-six amplified products of universal 16S rRNA were randomly recovered and sequenced. Results: The main clinical presentations reported were headache (51%), physical discomfort (51%), chill (32%) and fever (24, 5%). Only 3 blood cultures were positive. No positive PCR was obtained when using the Bartonella specific PCR either on blood or on cultured bacteria. However, all the PCR with the universal primers were positive. The sequenced 26 (49%) samples were identified as Sphingomonas spp. being this microorganism the causative agent of this outbreak. In 17% of the cases, patients were reported to have aquatic activities. Conclusion: Several Sphingomonas spp. infections in humans have been reported, mostly limited to sporadic case reports or intra-hospitalary outbreaks, but as far as we know this is the first outbreak of Sphingomonas spp. described in a non-hospital environment. 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La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
