Tumor neuroendocrino en cérvix uterino: reporte de caso

• Autores: Sandoval Díaz, Ither, Hernández Alarcón, Ronald, Palacios Cuervo, Fernando, Calderón Rivera, Andrea, Espinal Reyes, Fátima, Torres Arones, Esperanza, Delgado Elías, Andrea
• Formato: artículo
• Fecha de Publicación: 2015
• Institución: Universidad Peruana de Ciencias Aplicadas
• Repositorio: UPC-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorioacademico.upc.edu.pe:10757/550713
• Enlace del recurso: http://hdl.handle.net/10757/550713
• Nivel de acceso: acceso abierto
• Materia: Cáncer cérvico-uterino; Carcinoma neuroendocrino; Carcinoma de células pequeñas; Cervico uterine cancer; Neuroendocrine carcinoma; Small cell carcinoma

Neuroendocrine tumors of the cervix are extremely rare. Women diagnosed with small cell neuroendocrine carcinoma of the cervix have a higher frequency of metastases in the lymph nodes, lymphovascular invasion, recurrence and worse prognosis compared to those with other types of cervical neoplasia. We report the case of a 58-year-old female, with a history of six years of postmenopausal irregular vaginal bleeding, in addition to symptoms related to chronic anemia. Gynecological examination showed a tumor of 4 cm that occupied the upper third of the vagina and protruded through the cervix initially diagnosed as an abortifacient myoma, and sent to histopathology study. 90% of the tumor was small cell neuroendocrine carcinoma grade III, and the remaining 10% was squamous cell carcinoma. The patient underwent into a radical hysterectomy plus bilateral salpingo-oophorectomy, and bilateral pelvic and para-aortic lymphadenectomy. Histopathologic examination of the surgical specimen found endometrium and myometrium compromised by malignancy. Parametrium, annexes and lymph nodes were free of neoplasia. At microscopy, the result was a grade III neuroendocrine carcinoma (small cell carcinoma, infiltrating), with extensive lymphovascular emboli. The immune-histochemical study showed synaptophysin positive in areas with neuroendocrine differentiation.