Antiviral Treatment against Monkeypox: A Scoping Review

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uring the COVID-19 pandemic, the increase in reports of human monkeypox virus infection cases spreading in many countries outside Africa is a major cause for concern. Therefore, this study aimed to explore the evidence of antiviral pharmacotherapy available for the treatment of adult patients with m...

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Detalles Bibliográficos
Autores: Ortiz-Saavedra, Brando, León-Figueroa, Darwin A., Montes-Madariaga, Elizbet S., Ricardo-Martínez, Alex, Alva, Niza, Cabanillas-Ramirez, Cielo, Barboza, Joshuan J., Siddiq, Abdelmonem, Coaguila Cusicanqui, Luis A., Bonilla-Aldana, D. Katterine, Rodriguez-Morales, Alfonso J.
Formato: artículo
Fecha de Publicación:2022
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/668799
Enlace del recurso:http://hdl.handle.net/10757/668799
Nivel de acceso:acceso abierto
Materia:antiviral treatment
monkeypox
monkeypox virus
orthopoxvirus
scoping review
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dc.title.es_PE.fl_str_mv Antiviral Treatment against Monkeypox: A Scoping Review
title Antiviral Treatment against Monkeypox: A Scoping Review
spellingShingle Antiviral Treatment against Monkeypox: A Scoping Review
Ortiz-Saavedra, Brando
antiviral treatment
monkeypox
monkeypox virus
orthopoxvirus
scoping review
title_short Antiviral Treatment against Monkeypox: A Scoping Review
title_full Antiviral Treatment against Monkeypox: A Scoping Review
title_fullStr Antiviral Treatment against Monkeypox: A Scoping Review
title_full_unstemmed Antiviral Treatment against Monkeypox: A Scoping Review
title_sort Antiviral Treatment against Monkeypox: A Scoping Review
author Ortiz-Saavedra, Brando
author_facet Ortiz-Saavedra, Brando
León-Figueroa, Darwin A.
Montes-Madariaga, Elizbet S.
Ricardo-Martínez, Alex
Alva, Niza
Cabanillas-Ramirez, Cielo
Barboza, Joshuan J.
Siddiq, Abdelmonem
Coaguila Cusicanqui, Luis A.
Bonilla-Aldana, D. Katterine
Rodriguez-Morales, Alfonso J.
author_role author
author2 León-Figueroa, Darwin A.
Montes-Madariaga, Elizbet S.
Ricardo-Martínez, Alex
Alva, Niza
Cabanillas-Ramirez, Cielo
Barboza, Joshuan J.
Siddiq, Abdelmonem
Coaguila Cusicanqui, Luis A.
Bonilla-Aldana, D. Katterine
Rodriguez-Morales, Alfonso J.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Ortiz-Saavedra, Brando
León-Figueroa, Darwin A.
Montes-Madariaga, Elizbet S.
Ricardo-Martínez, Alex
Alva, Niza
Cabanillas-Ramirez, Cielo
Barboza, Joshuan J.
Siddiq, Abdelmonem
Coaguila Cusicanqui, Luis A.
Bonilla-Aldana, D. Katterine
Rodriguez-Morales, Alfonso J.
dc.subject.es_PE.fl_str_mv antiviral treatment
monkeypox
monkeypox virus
orthopoxvirus
scoping review
topic antiviral treatment
monkeypox
monkeypox virus
orthopoxvirus
scoping review
description uring the COVID-19 pandemic, the increase in reports of human monkeypox virus infection cases spreading in many countries outside Africa is a major cause for concern. Therefore, this study aimed to explore the evidence of antiviral pharmacotherapy available for the treatment of adult patients with monkeypox. A scoping review of the literature was conducted using PubMed, Scopus, Web of Science, Embase, and CENTRAL databases until 12 September 2022. The key search terms used were “monkeypox” and “treatment”. A total of 1927 articles were retrieved using the search strategy. After removing duplicates (n = 1007) and examining by title, abstract, and full text, 11 studies reporting case reports of monkeypox with antiviral treatment were included, detailing the number of monkeypox cases, clinical manifestations, number of participants with antiviral treatment, history of sexually transmitted diseases, method of diagnosis, location of skin lesions, drugs used in antiviral treatment, route of administration, and outcome. A total of 1281 confirmed cases of monkeypox have been reported, of which 65 monkeypox cases had antiviral treatment distributed most frequently in the United States (n = 30), the United Kingdom (n = 6), and Spain (n = 6). Of the total cases, 1269 (99.1%) were male with an age range of 18 to 76 years, and 1226 (95.7%) had a sexual behavior of being men who have sex with men. All confirmed cases of monkeypox were diagnosed by reverse transcriptase polymerase chain reaction (RT-PCR). The most frequent clinical manifestations were skin lesions, fever, lymphadenopathy, headache, fatigue, and myalgia. The most frequent locations of the lesions were perianal, genital, facial, and upper and lower extremities. The most commonly used drugs for antiviral treatment of monkeypox were: tecovirimat, cidofovir, and brincidofovir. All patients had a complete recovery. According to current evidence, the efficacy and safety of antiviral drugs against monkeypox is of low quality and scarce.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2023-09-27T17:02:04Z
dc.date.available.none.fl_str_mv 2023-09-27T17:02:04Z
dc.date.issued.fl_str_mv 2022-11-01
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.doi.none.fl_str_mv 10.3390/tropicalmed7110369
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10757/668799
dc.identifier.eissn.none.fl_str_mv 24146366
dc.identifier.journal.es_PE.fl_str_mv Tropical Medicine and Infectious Disease
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dc.language.iso.es_PE.fl_str_mv eng
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dc.publisher.es_PE.fl_str_mv MDPI
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Academico - UPC
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dc.source.journaltitle.none.fl_str_mv Tropical Medicine and Infectious Disease
dc.source.volume.none.fl_str_mv 7
dc.source.issue.none.fl_str_mv 11
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KatterineRodriguez-Morales, Alfonso J.2023-09-27T17:02:04Z2023-09-27T17:02:04Z2022-11-0110.3390/tropicalmed7110369http://hdl.handle.net/10757/66879924146366Tropical Medicine and Infectious Disease2-s2.0-85141569794SCOPUS_ID:851415697940000 0001 2196 144X047xrr705uring the COVID-19 pandemic, the increase in reports of human monkeypox virus infection cases spreading in many countries outside Africa is a major cause for concern. Therefore, this study aimed to explore the evidence of antiviral pharmacotherapy available for the treatment of adult patients with monkeypox. A scoping review of the literature was conducted using PubMed, Scopus, Web of Science, Embase, and CENTRAL databases until 12 September 2022. The key search terms used were “monkeypox” and “treatment”. A total of 1927 articles were retrieved using the search strategy. After removing duplicates (n = 1007) and examining by title, abstract, and full text, 11 studies reporting case reports of monkeypox with antiviral treatment were included, detailing the number of monkeypox cases, clinical manifestations, number of participants with antiviral treatment, history of sexually transmitted diseases, method of diagnosis, location of skin lesions, drugs used in antiviral treatment, route of administration, and outcome. A total of 1281 confirmed cases of monkeypox have been reported, of which 65 monkeypox cases had antiviral treatment distributed most frequently in the United States (n = 30), the United Kingdom (n = 6), and Spain (n = 6). Of the total cases, 1269 (99.1%) were male with an age range of 18 to 76 years, and 1226 (95.7%) had a sexual behavior of being men who have sex with men. All confirmed cases of monkeypox were diagnosed by reverse transcriptase polymerase chain reaction (RT-PCR). The most frequent clinical manifestations were skin lesions, fever, lymphadenopathy, headache, fatigue, and myalgia. The most frequent locations of the lesions were perianal, genital, facial, and upper and lower extremities. The most commonly used drugs for antiviral treatment of monkeypox were: tecovirimat, cidofovir, and brincidofovir. All patients had a complete recovery. 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