Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials

Descripción del Articulo

faustino.perez@unizar.es
Detalles Bibliográficos
Autores: Perez López, Faustino R., Pasupuleti, Vinay, Thota, Priyaleela, Deshpande, Abhishek, Hernández, Adrian V., Mezones-Holguín, Edward, Benítes-Zapata, Vicente A.
Formato: artículo
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/347325
Enlace del recurso:https://doi.org/10.1016/j.fertnstert.2015.02.019
http://hdl.handle.net/10757/347325
Nivel de acceso:acceso abierto
Materia:Vitamin D
Pregnancy
Maternal outcomes
Neonatal outcomes
Meta-analysis
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dc.title.es_PE.fl_str_mv Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
title Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
spellingShingle Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
Perez López, Faustino R.
Vitamin D
Pregnancy
Maternal outcomes
Neonatal outcomes
Meta-analysis
title_short Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
title_full Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
title_fullStr Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
title_full_unstemmed Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
title_sort Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
author Perez López, Faustino R.
author_facet Perez López, Faustino R.
Pasupuleti, Vinay
Thota, Priyaleela
Deshpande, Abhishek
Hernández, Adrian V.
Mezones-Holguín, Edward
Benítes-Zapata, Vicente A.
author_role author
author2 Pasupuleti, Vinay
Thota, Priyaleela
Deshpande, Abhishek
Hernández, Adrian V.
Mezones-Holguín, Edward
Benítes-Zapata, Vicente A.
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Perez López, Faustino R.
Pasupuleti, Vinay
Thota, Priyaleela
Deshpande, Abhishek
Hernández, Adrian V.
Mezones-Holguín, Edward
Benítes-Zapata, Vicente A.
dc.subject.es_PE.fl_str_mv Vitamin D
Pregnancy
Maternal outcomes
Neonatal outcomes
Meta-analysis
topic Vitamin D
Pregnancy
Maternal outcomes
Neonatal outcomes
Meta-analysis
description faustino.perez@unizar.es
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2015-03-30T19:31:08Z
dc.date.available.es_PE.fl_str_mv 2015-03-30T19:31:08Z
dc.date.issued.fl_str_mv 2015-03-30
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.es_PE.fl_str_mv Pasupuleti V, Mezones-holguin E, Benites-zapata VA, Thota P, Deshpande A, Hernandez A V. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes : a systematic review and meta-analysis of randomized controlled trials. Fertil Steril [Internet]. 2015;(Feb). Available from: http://hdl.handle.net/10757/347325
dc.identifier.issn.es_PE.fl_str_mv 0015-0282
dc.identifier.doi.es_PE.fl_str_mv https://doi.org/10.1016/j.fertnstert.2015.02.019
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/347325
dc.identifier.eissn.es_PE.fl_str_mv 1556-5653
dc.identifier.journal.es_PE.fl_str_mv Fertility and Sterility
identifier_str_mv Pasupuleti V, Mezones-holguin E, Benites-zapata VA, Thota P, Deshpande A, Hernandez A V. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes : a systematic review and meta-analysis of randomized controlled trials. Fertil Steril [Internet]. 2015;(Feb). Available from: http://hdl.handle.net/10757/347325
0015-0282
1556-5653
Fertility and Sterility
url https://doi.org/10.1016/j.fertnstert.2015.02.019
http://hdl.handle.net/10757/347325
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.fertstert.org/article/S0015-0282%2815%2900149-1/abstract
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dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Elsevier B.V.
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
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spelling virtual::302-1virtual::1271-1Perez López, Faustino R.Pasupuleti, VinayThota, PriyaleelaDeshpande, AbhishekHernández, Adrian V.Mezones-Holguín, EdwardBenítes-Zapata, Vicente A.2015-03-30T19:31:08Z2015-03-30T19:31:08Z2015-03-30Pasupuleti V, Mezones-holguin E, Benites-zapata VA, Thota P, Deshpande A, Hernandez A V. Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes : a systematic review and meta-analysis of randomized controlled trials. Fertil Steril [Internet]. 2015;(Feb). Available from: http://hdl.handle.net/10757/3473250015-0282https://doi.org/10.1016/j.fertnstert.2015.02.019http://hdl.handle.net/10757/3473251556-5653Fertility and Sterilityfaustino.perez@unizar.esObjective: To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables. Design: Systematic review and meta-analysis of randomized controlled trials (RCTs). Setting: Not applicable. Patient(s): Pregnant women and neonates. Intervention(s): PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy. Main Outcome Measure(s): Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs). Result(s): Thirteen RCTs (n ¼ 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2–66.7). Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference: 107.6 g (95% CI 59.9–155.3 g) and 0.3 cm (95% CI 0.10–0.41 cm), respectively. Incidence of preeclampsia, GDM, SGA, low birth weight, preterm birth, and cesarean section were not influenced by vitamin D supplementation. Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous. Conclusion(s): Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion. (Fertil Steril 2015;-:-–-. 2015 by American Society for Reproductive Medicine.)Revisión por paresapplication/pdfengElsevier B.V.http://www.fertstert.org/article/S0015-0282%2815%2900149-1/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/Universidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCVitamin DPregnancyMaternal outcomesNeonatal outcomesMeta-analysisEffect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trialsinfo:eu-repo/semantics/articlehttp://purl.org/coar/version/c_970fb48d4fbd8a8532018-06-16T23:43:41ZObjective: To assess the effects of vitamin D supplementation during pregnancy on obstetric outcomes and birth variables. Design: Systematic review and meta-analysis of randomized controlled trials (RCTs). Setting: Not applicable. Patient(s): Pregnant women and neonates. Intervention(s): PubMed and 5 other research databases were searched through March 2014 for RCTs evaluating vitamin D supplementation calcium/vitamins/ferrous sulfate vs. a control (placebo or active) during pregnancy. Main Outcome Measure(s): Measures were: circulating 25-hydroxyvitamin D [25(OH)D] levels, preeclampsia, gestational diabetes mellitus (GDM), small for gestational age (SGA), low birth weight, preterm birth, birth weight, birth length, cesarean section. Mantel-Haenszel fixed-effects models were used, owing to expected scarcity of outcomes. Effects were reported as relative risks and their 95% confidence intervals (CIs). Result(s): Thirteen RCTs (n ¼ 2,299) were selected. Circulating 25(OH)D levels were significantly higher at term, compared with the control group (mean difference: 66.5 nmol/L, 95% CI 66.2–66.7). Birth weight and birth length were significantly greater for neonates in the vitamin D group; mean difference: 107.6 g (95% CI 59.9–155.3 g) and 0.3 cm (95% CI 0.10–0.41 cm), respectively. Incidence of preeclampsia, GDM, SGA, low birth weight, preterm birth, and cesarean section were not influenced by vitamin D supplementation. Across RCTs, the doses and types of vitamin D supplements, gestational age at first administration, and outcomes were heterogeneous. Conclusion(s): Vitamin D supplementation during pregnancy was associated with increased circulating 25(OH)D levels, birth weight, and birth length, and was not associated with other maternal and neonatal outcomes. Larger, better-designed RCTs evaluating clinically relevant outcomes are necessary to reach a definitive conclusion. 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Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials
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