Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department

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16th ICID Abstracts / International Journal of Infectious Diseases 21S (2014) 1–460. Final Abstract Number: 52.007. Session: Epidemiology and Public Health II Date: Friday, April 4, 2014. Time: 12:45-14:15 Room: Ballroom
Detalles Bibliográficos
Autores: Cornejo Tapia, Ángela, Casabona, V., Gomes, C.S.P., Tinco, C., Martinez Pucho, S., Suárez Ognio, Luis, Ruiz, J., Del Valle Mendoza, Juana
Formato: objeto de conferencia
Fecha de Publicación:2015
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/347058
Enlace del recurso:http://dx.doi.org/10.1016/j.ijid.2014.03.924
http://hdl.handle.net/10757/347058
Nivel de acceso:acceso abierto
Materia:https://purl.org/pe-repo/ocde/ford#3.00.00
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dc.title.es_PE.fl_str_mv Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
title Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
spellingShingle Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
Cornejo Tapia, Ángela
https://purl.org/pe-repo/ocde/ford#3.00.00
title_short Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
title_full Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
title_fullStr Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
title_full_unstemmed Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
title_sort Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
author Cornejo Tapia, Ángela
author_facet Cornejo Tapia, Ángela
Casabona, V.
Gomes, C.S.P.
Tinco, C.
Martinez Pucho, S.
Suárez Ognio, Luis
Ruiz, J.
Del Valle Mendoza, Juana
author_role author
author2 Casabona, V.
Gomes, C.S.P.
Tinco, C.
Martinez Pucho, S.
Suárez Ognio, Luis
Ruiz, J.
Del Valle Mendoza, Juana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cornejo Tapia, Ángela
Casabona, V.
Gomes, C.S.P.
Tinco, C.
Martinez Pucho, S.
Suárez Ognio, Luis
Ruiz, J.
Del Valle Mendoza, Juana
dc.subject.ocde.es_PE.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.00.00
topic https://purl.org/pe-repo/ocde/ford#3.00.00
description 16th ICID Abstracts / International Journal of Infectious Diseases 21S (2014) 1–460. Final Abstract Number: 52.007. Session: Epidemiology and Public Health II Date: Friday, April 4, 2014. Time: 12:45-14:15 Room: Ballroom
publishDate 2015
dc.date.accessioned.es_PE.fl_str_mv 2015-03-23T23:04:46Z
dc.date.available.es_PE.fl_str_mv 2015-03-23T23:04:46Z
dc.date.issued.fl_str_mv 2015-03-23
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dc.identifier.citation.es_PE.fl_str_mv 1. Cornejo a., Casabona V, Gomes CSP, Tinco C, Martinez-Puchol S, Suarez L, et al. Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department. Int J Infect Dis [Internet]. International Society for Infectious Diseases; 2014;21:242. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1201971214009837
dc.identifier.issn.es_PE.fl_str_mv 1201-9712
dc.identifier.doi.es_PE.fl_str_mv http://dx.doi.org/10.1016/j.ijid.2014.03.924
dc.identifier.uri.es_PE.fl_str_mv http://hdl.handle.net/10757/347058
dc.identifier.journal.es_PE.fl_str_mv International Journal of Infectious Diseases
identifier_str_mv 1. Cornejo a., Casabona V, Gomes CSP, Tinco C, Martinez-Puchol S, Suarez L, et al. Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department. Int J Infect Dis [Internet]. International Society for Infectious Diseases; 2014;21:242. Available from: http://linkinghub.elsevier.com/retrieve/pii/S1201971214009837
1201-9712
International Journal of Infectious Diseases
url http://dx.doi.org/10.1016/j.ijid.2014.03.924
http://hdl.handle.net/10757/347058
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv http://www.sciencedirect.com/science/article/pii/S1201971214009837
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Elsevier B.V.
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Académico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
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spelling 4bc89643717c319fcd497b3e004bd043-10f6904b8f8c0f4a8a31c663bf4c22932-1515a5adbde9111a13f6a7a625ec257fd-1937c649056ba843bfd8afeec8df370cf-1c6ffb559091b4bd8fd8f1d3451bebc51-1c656a686a8c259715ddc24f486e02def-1ea4494b3c2da7e9ff48f961207fed373-1f92b24b86b6890d5ff7acafea7fac632-1Cornejo Tapia, ÁngelaCasabona, V.Gomes, C.S.P.Tinco, C.Martinez Pucho, S.Suárez Ognio, LuisRuiz, J.Del Valle Mendoza, Juana2015-03-23T23:04:46Z2015-03-23T23:04:46Z2015-03-231. Cornejo a., Casabona V, Gomes CSP, Tinco C, Martinez-Puchol S, Suarez L, et al. Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department. Int J Infect Dis [Internet]. International Society for Infectious Diseases; 2014;21:242. Available from: http://linkinghub.elsevier.com/retrieve/pii/S12019712140098371201-9712http://dx.doi.org/10.1016/j.ijid.2014.03.924http://hdl.handle.net/10757/347058International Journal of Infectious Diseases16th ICID Abstracts / International Journal of Infectious Diseases 21S (2014) 1–460. Final Abstract Number: 52.007. Session: Epidemiology and Public Health II Date: Friday, April 4, 2014. Time: 12:45-14:15 Room: BallroomBackground: In March 2013, the presence of an outbreak of Bartonella bacilliformis in the Rodriguez de Mendoza (Amazonas department, Peru) was reported. B. bacilliformis is an endemic pathogen of the Andean region, responsible for Carrion’s disease. One of the main problems of this illness is the lack of adequate technical and human resources for proper diagnosis in endemic rural areas. The objective of this study was to characterize a supposed B. bacilliformis outbreak, internationally informed in Rodriguez de Mendoza province. Methods & Materials: Fifty-three blood samples were recovered from people diagnosed with Carrion’s disease, either by optical microscopy and/or clinical manifestations. In all cases epidemiological and clinical data were recorded. The samples were cultured on Columbia Agar adding 10% of sheep blood and incubated at 28 ◦C for a period of 10 weeks. Every 14 days the plates were visually inspected to detect any bacterial growth. Additionally, the DNA was directly extracted from blood and 2 different 16S rRNA PCR schemes were used, one specific for Bartonella genus and other using universal primers. Twenty-six amplified products of universal 16S rRNA were randomly recovered and sequenced. Results: The main clinical presentations reported were headache (51%), physical discomfort (51%), chill (32%) and fever (24, 5%). Only 3 blood cultures were positive. No positive PCR was obtained when using the Bartonella specific PCR either on blood or on cultured bacteria. However, all the PCR with the universal primers were positive. The sequenced 26 (49%) samples were identified as Sphingomonas spp. being this microorganism the causative agent of this outbreak. In 17% of the cases, patients were reported to have aquatic activities. Conclusion: Several Sphingomonas spp. infections in humans have been reported, mostly limited to sporadic case reports or intra-hospitalary outbreaks, but as far as we know this is the first outbreak of Sphingomonas spp. described in a non-hospital environment. The association between 17% of patients with aquatic activities suggests that this was the most feasible transmission way. Training of health staff and development of new diagnostic able to be implemented in rural endemic areas is urgent in order to overcome wrong diagnostics and avoid wrong treatments.application/pdfengElsevier B.V.http://www.sciencedirect.com/science/article/pii/S1201971214009837info:eu-repo/semantics/openAccessUniversidad Peruana de Ciencias Aplicadas (UPC)Repositorio Académico - UPCreponame:UPC-Institucionalinstname:Universidad Peruana de Ciencias Aplicadasinstacron:UPCMisdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon departmentinfo:eu-repo/semantics/conferenceObjecthttps://purl.org/pe-repo/ocde/ford#3.00.002018-06-16T13:07:18ZBackground: In March 2013, the presence of an outbreak of Bartonella bacilliformis in the Rodriguez de Mendoza (Amazonas department, Peru) was reported. B. bacilliformis is an endemic pathogen of the Andean region, responsible for Carrion’s disease. One of the main problems of this illness is the lack of adequate technical and human resources for proper diagnosis in endemic rural areas. The objective of this study was to characterize a supposed B. bacilliformis outbreak, internationally informed in Rodriguez de Mendoza province. Methods & Materials: Fifty-three blood samples were recovered from people diagnosed with Carrion’s disease, either by optical microscopy and/or clinical manifestations. In all cases epidemiological and clinical data were recorded. The samples were cultured on Columbia Agar adding 10% of sheep blood and incubated at 28 ◦C for a period of 10 weeks. Every 14 days the plates were visually inspected to detect any bacterial growth. Additionally, the DNA was directly extracted from blood and 2 different 16S rRNA PCR schemes were used, one specific for Bartonella genus and other using universal primers. Twenty-six amplified products of universal 16S rRNA were randomly recovered and sequenced. Results: The main clinical presentations reported were headache (51%), physical discomfort (51%), chill (32%) and fever (24, 5%). Only 3 blood cultures were positive. No positive PCR was obtained when using the Bartonella specific PCR either on blood or on cultured bacteria. However, all the PCR with the universal primers were positive. The sequenced 26 (49%) samples were identified as Sphingomonas spp. being this microorganism the causative agent of this outbreak. In 17% of the cases, patients were reported to have aquatic activities. Conclusion: Several Sphingomonas spp. infections in humans have been reported, mostly limited to sporadic case reports or intra-hospitalary outbreaks, but as far as we know this is the first outbreak of Sphingomonas spp. described in a non-hospital environment. The association between 17% of patients with aquatic activities suggests that this was the most feasible transmission way. 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Misdiagnosed outbreak of bartonella bacilliformis in Peruvian Amazon department
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