Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes

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We analyzed the accumulation of population polymorphism in 2504 individuals - nuclear genomes (nDNA) of 26 populations (81 genes associated to extreme environments) and 3295 mitochondrial genomes (mtDNA) of 47 populations with the aim to found mitonuclear relationship associated an extremes environm...

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Detalles Bibliográficos
Autores: Iannacone, G. C., Ramírez, P.
Formato: artículo
Fecha de Publicación:2022
Institución:Universidad Peruana de Ciencias Aplicadas
Repositorio:UPC-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorioacademico.upc.edu.pe:10757/668778
Enlace del recurso:http://hdl.handle.net/10757/668778
Nivel de acceso:acceso abierto
Materia:DNA polymorphism
Extreme environmental
Forensic DNA
Genome
Mitonuclear interaction
Population genomic
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dc.title.es_PE.fl_str_mv Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
title Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
spellingShingle Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
Iannacone, G. C.
DNA polymorphism
Extreme environmental
Forensic DNA
Genome
Mitonuclear interaction
Population genomic
title_short Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
title_full Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
title_fullStr Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
title_full_unstemmed Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
title_sort Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
author Iannacone, G. C.
author_facet Iannacone, G. C.
Ramírez, P.
author_role author
author2 Ramírez, P.
author2_role author
dc.contributor.author.fl_str_mv Iannacone, G. C.
Ramírez, P.
dc.subject.es_PE.fl_str_mv DNA polymorphism
Extreme environmental
Forensic DNA
Genome
Mitonuclear interaction
Population genomic
topic DNA polymorphism
Extreme environmental
Forensic DNA
Genome
Mitonuclear interaction
Population genomic
description We analyzed the accumulation of population polymorphism in 2504 individuals - nuclear genomes (nDNA) of 26 populations (81 genes associated to extreme environments) and 3295 mitochondrial genomes (mtDNA) of 47 populations with the aim to found mitonuclear relationship associated an extremes environment as altitude. For that, we use an algorithm developed by us to determine the accumulation of polymorphisms by segments in the genome and thus be able to perform the multivariate analysis to found SNPs differences and similarities among populations. The results showed in Peruvian population a statistically significant mitonuclear relationship for 113/293970 nDNA SNPs in 16/81 genes. In the case of the mtDNA, we found a statistically significant mitonuclear relationship for 6/22 mtDNA positions – Gene. Additionally for the Peruvian population, the MRPP3 had the greatest polymorphism contribution with respect to other populations. Then, these nDNA and mtDNA SNPs in genetically close populations to Peru can be applied to forensic genomic phenotyping to identify groups likely adapted to extreme conditions (such as altitude) or make individualization between low and high altitude populations.
publishDate 2022
dc.date.accessioned.none.fl_str_mv 2023-09-26T18:03:00Z
dc.date.available.none.fl_str_mv 2023-09-26T18:03:00Z
dc.date.issued.fl_str_mv 2022-12-01
dc.type.es_PE.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.issn.none.fl_str_mv 18751768
dc.identifier.doi.none.fl_str_mv 10.1016/j.fsigss.2022.09.027
dc.identifier.uri.none.fl_str_mv http://hdl.handle.net/10757/668778
dc.identifier.eissn.none.fl_str_mv 1875175X
dc.identifier.journal.es_PE.fl_str_mv Forensic Science International: Genetics Supplement Series
dc.identifier.eid.none.fl_str_mv 2-s2.0-85140248369
dc.identifier.scopusid.none.fl_str_mv SCOPUS_ID:85140248369
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identifier_str_mv 18751768
10.1016/j.fsigss.2022.09.027
1875175X
Forensic Science International: Genetics Supplement Series
2-s2.0-85140248369
SCOPUS_ID:85140248369
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0000 0001 2196 144X
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url http://hdl.handle.net/10757/668778
dc.language.iso.es_PE.fl_str_mv eng
language eng
dc.relation.url.es_PE.fl_str_mv https://www.sciencedirect.com/science/article/pii/S1875176822000269
dc.rights.es_PE.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.*.fl_str_mv Attribution-NonCommercial-ShareAlike 4.0 International
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eu_rights_str_mv openAccess
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dc.format.es_PE.fl_str_mv application/pdf
dc.publisher.es_PE.fl_str_mv Elsevier B.V.
dc.source.es_PE.fl_str_mv Universidad Peruana de Ciencias Aplicadas (UPC)
Repositorio Academico - UPC
dc.source.none.fl_str_mv reponame:UPC-Institucional
instname:Universidad Peruana de Ciencias Aplicadas
instacron:UPC
instname_str Universidad Peruana de Ciencias Aplicadas
instacron_str UPC
institution UPC
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collection UPC-Institucional
dc.source.journaltitle.none.fl_str_mv Forensic Science International: Genetics Supplement Series
dc.source.volume.none.fl_str_mv 8
dc.source.beginpage.none.fl_str_mv 74
dc.source.endpage.none.fl_str_mv 76
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spelling 8fc4b4cea020427f3f16e37c2fa96429300c23826f0bafc882a6a83ab38656f8f7e300Iannacone, G. C.Ramírez, P.2023-09-26T18:03:00Z2023-09-26T18:03:00Z2022-12-011875176810.1016/j.fsigss.2022.09.027http://hdl.handle.net/10757/6687781875175XForensic Science International: Genetics Supplement Series2-s2.0-85140248369SCOPUS_ID:85140248369S18751768220002690000 0001 2196 144X047xrr705We analyzed the accumulation of population polymorphism in 2504 individuals - nuclear genomes (nDNA) of 26 populations (81 genes associated to extreme environments) and 3295 mitochondrial genomes (mtDNA) of 47 populations with the aim to found mitonuclear relationship associated an extremes environment as altitude. For that, we use an algorithm developed by us to determine the accumulation of polymorphisms by segments in the genome and thus be able to perform the multivariate analysis to found SNPs differences and similarities among populations. The results showed in Peruvian population a statistically significant mitonuclear relationship for 113/293970 nDNA SNPs in 16/81 genes. In the case of the mtDNA, we found a statistically significant mitonuclear relationship for 6/22 mtDNA positions – Gene. Additionally for the Peruvian population, the MRPP3 had the greatest polymorphism contribution with respect to other populations. 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Accumulation of population polymorphisms in the mitonuclear genome with probable adaptive effect to extreme environments as altitude for forensic purposes
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