Serological and molecular detection of dengue virus in animals: A systematic review and meta-analysis

• Autores: Bonilla-Aldana, D. Katterine, Rodas-Fuenmayor, Marcela María, Ruiz-Aristizabal, Luisa María, Ulloque-Badaracco, Juan R., Alarcón-Braga, Esteban A., Hernandez-Bustamante, Enrique A., Cabrera-Guzman, Juan C., Ulloque-Badaracco, Ricardo R., Benites-Zapata, Vicente A., Rodriguez-Morales, Alfonso J.
• Formato: artículo
• Fecha de Publicación: 2024
• Institución: Universidad Peruana de Ciencias Aplicadas
• Repositorio: UPC-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorioacademico.upc.edu.pe:10757/675840
• Enlace del recurso: https://doi.org/10.53854/liim-3202-7; http://hdl.handle.net/10757/675840
• Nivel de acceso: acceso abierto
• Materia: and meta-analysis; Animals; dengue; systematic review; virus; zoonosis; https://purl.org/pe-repo/ocde/ford#3.00.00

Introduction: Dengue is a vector-borne disease, especially important in tropical and subtropical areas. The first presentation of many arboviral diseases occurred mainly in animals, including multiple Alphaviruses and Flaviviruses, such as dengue. Objective: To determine the serological and molecular frequency of the dengue virus in animals. Methods: A systematic literature review was carried out in five databases for the proportion of animals infected with dengue, defined by molecular and serological tests. A meta-analysis was performed using a randomeffects model to calculate the pooled prevalence and 95% confidence intervals (CI). Cochran?s Q test and the I2 statistic were used to assess the heterogeneity between the two studies. Results: The presence of dengue in bats, primates, birds, sheep, horses, cattle, pigs, rodents and buffaloes, according to serological methods, had a prevalence of 10%, 29%, 8%, 1%, 11%, 0%, 49%, 2%, 7%, respectively. According to molecular methods, the presence of dengue in bats had a seroprevalence of 6.0%. Conclusion: The present study confirms the presence of the Dengue virus in a large group of animal species, with potential implications as possible reservoirs of this virus, raising the possibility of zoonotic transmission.