Screening fitoquímico y efecto analgésico del extracto hidroalcohólico de las hojas de Peperomia dolabriformis Kunth en Mus musculus BALB/c

• Autores: Alfaro TTito, Bertha Mirella, García Rodríguez, Yesica Paola
• Formato: tesis de grado
• Fecha de Publicación: 2018
• Institución: Universidad Nacional de Trujillo
• Repositorio: UNITRU-Tesis
• Lenguaje: español
• OAI Identifier: oai:dspace.unitru.edu.pe:20.500.14414/10404
• Enlace del recurso: https://hdl.handle.net/20.500.14414/10404
• Nivel de acceso: acceso abierto
• Materia: congona de zorro, Peperomia dolabriformis, fitoquímica, analgesia

The objective of this study was to perform preliminary phytochemical screening and to determine the analgesic effect of the hydroalcoholic extract of the leaves of Peperomia dolabriformis Kunth "congona de zorro". The leaves were collected from the Coastal Hills of Cerro Campana, district of Huanchaco. The hydroalcoholic extract was prepared by maceration. The evaluation of analgesic effect was carried out by Acetic acid-induced writhing in mice method. The hydroalcoholic extract presented the following metabolites: catechins, lactones and coumarins, oils and fats, triterpenes and steroids, phenolic compounds, flavonoids, anthocyanidin, resins, reducing sugars, tannins and amino acids. Besides, the hydroalcoholic extracts at doses of 10 mg / kg, 20 mg / kg and 30 mg / kg showed analgesic effect with percentages of inhibition of the number of abdominal contortions of 35%, 66.08% and 88.11% respectively and with statistically significant differences (p <0.05). The doses of 30 mg / kg presented greater percentage of inhibition of the number of contortions than Indometacin 10mg / Kg (78.78%). This work is the first report of the bioactivity of this plant species, which is an attractive option for the development of new drugs