Actividad inhibitoria in vitro de corteza de Maytenus macrocarpa (Ruiz & Pav.) Briq., Erythrina fusca Lour y hojas de Calathea lutea Schult sobre α- glucosidasa

• Autor: Ramírez Cárdenas, Christian Rafael
• Formato: tesis de grado
• Fecha de Publicación: 2023
• Institución: Universidad Nacional De La Amazonía Peruana
• Repositorio: UNAPIquitos-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.unapiquitos.edu.pe:20.500.12737/9442
• Enlace del recurso: https://hdl.handle.net/20.500.12737/9442
• Nivel de acceso: acceso abierto
• Materia: Inhibidores de enzimas; In vitro; Corteza; Alfa glucosidasa; Chuchuhuasi; Bijao; Calathea lutea; Maytenus macrocarpa; Erythrina fusca; https://purl.org/pe-repo/ocde/ford#1.06.03

α-Glucosidase inhibitors slow the absorption of carbohydrates in the intestine and can be used in people with type 2 diabetes. The aim of the study was to determine the inhibitory activity of the bark of Maytenus macrocarpa (Ruiz & Pav.) Briq., Erythrina fusca Lour and Calathea lutea Schult leaves on α – glucosidase, evaluated at concentrations of 100, 250, 500 and 1000 µg/mL. The results showed that the bark of M. macrocarpa (Ruiz & Pav.) Briq. presented an inhibition greater than 50% at 1000 µg/mL; unlike the extracts of the bark of E. fusca Lour and leaves of C. lutea Schult. The inhibitory concentration (IC50) for bark of M. macrocarpa (Ruiz & Pav.) Briq. it was an IC50=935.00 µg; bark of E. fusca Lour and leaves of C. lutea Schult were not considered active; which allows us to conclude that the bark of M. macrocarpa (Ruiz & Pav.) Briq had the best inhibitory effect, so this species could be considered promising in the adjuvant treatment of type 2 diabetes.