Prevalencia de fragilidad en pacientes mayores de 60 años, con enfermedad renal crónica en hemodiálisis, atendidos en la Unidad de Nefrología del Hospital Regional de Loreto entre enero a junio del 2025”

• Autor: Azabache Chero, Pierre Ivan
• Formato: tesis de maestría
• Fecha de Publicación: 2025
• Institución: Universidad Nacional De La Amazonía Peruana
• Repositorio: UNAPIquitos-Institucional
• Lenguaje: español
• OAI Identifier: oai:repositorio.unapiquitos.edu.pe:20.500.12737/12091
• Enlace del recurso: https://hdl.handle.net/20.500.12737/12091
• Nivel de acceso: acceso abierto
• Materia: Fragilidad; Anciano; Prevalencia; Insuficiencia renal crónica; Hemodiálisis; https://purl.org/pe-repo/ocde/ford#3.02.27

Frailty represents a recognized biological condition marked by reduced physiological reserve and diminished capacity to cope with stressors, ultimately increasing susceptibility to negative health outcomes. This syndrome unfolds progressively, affecting various bodily systems through cumulative functional decline. Studies report that frailty affects approximately 7% of individuals with early-stage chronic kidney disease (CKD, stages I–IV), and up to 73% of patients receiving hemodialysis. As a complex clinical condition involving multiple systems, frailty stems from a combination of vascular dysfunction, chronic inflammation, poor nutritional status, and aging-related changes. These factors accelerate biological aging and contribute to diminished functional capacity and greater vulnerability. Although first observed among older adults living in the community, frailty has become a critical indicator for identifying patients at elevated risk of death or institutional care, particularly in populations undergoing dialysis. Frailty is frequently observed in individuals with CKD. Epidemiological data from various countries indicate that people aged 65 and older comprise the most substantial and an increasingly large proportion of individuals with end-stage renal disease. It is crucial to distinguish frailty from chronological aging, as they are separate constructs. Consequently, advancing our understanding of frailty and its relationship with CKD has become a key public health concern for clinicians, researchers, and policymakers alike. Importantly, research suggests that frailty is not irreversible. Interventions such as structured physical activity, nutritional support, cognitive stimulation, and psychological counseling have shown potential in mitigating frailty. Early detection in CKD patients who are not yet on dialysis may facilitate timely and focused interventions that could enhance survival outcomes and postpone dialysis initiation.