Eficacia terapéutica de cloroquina más primaquina en malaria vivax no complicada en dos comunidades de la amazonía peruana

Descripción del Articulo

Resistance and therapeutic failure to Plasmodium vivax treatment is an increasing problem due to parasite recurrences that sustain transmission. This study aimed to describe clinical and parasitological response after initiation of supervised radical cure treatment in two villages in the Peruvian Am...

Descripción completa

Detalles Bibliográficos
Autor: Guzmán Guzmán, Mitchel Anthony
Formato: tesis de maestría
Fecha de Publicación:2023
Institución:Universidad Nacional De La Amazonía Peruana
Repositorio:UNAPIquitos-Institucional
Lenguaje:español
OAI Identifier:oai:repositorio.unapiquitos.edu.pe:20.500.12737/9168
Enlace del recurso:https://hdl.handle.net/20.500.12737/9168
Nivel de acceso:acceso abierto
Materia:Malaria vivax
Resultado del tratamiento
Eficacia
Cloroquina
Primaquina
Antimaláricos
https://purl.org/pe-repo/ocde/ford#3.03.06
Descripción
Sumario:Resistance and therapeutic failure to Plasmodium vivax treatment is an increasing problem due to parasite recurrences that sustain transmission. This study aimed to describe clinical and parasitological response after initiation of supervised radical cure treatment in two villages in the Peruvian Amazon follow up by both, molecular tools (qPCR) and thick smear, for 28 days. Thirty-one participants with uncomplicated vivax malaria were recruited from March 2016 to January 2017 in Santa Emilia and San José de Lupuna, river travel is the only way from these endemic rural villages to other places. At the recruitment (day 0), treatment was started with chloroquine 25mg/Kg in 3 days plus primaquine 0.5 mg/Kg/day for 7 days (according to national guidelines in Peru). Clinical and parasitological evaluations were done on days 2, 3, 7, 14, 21 and 28. Although more therapeutic failures were detected by qPCR (n=8) than by microscopy (n=4), such that cumulative incidence efficacy by microscopy was 86.6% (IC95, 75.2 – 99.8%), and 70.8% (IC95, 55.5 – 90.3%) by qPCR, no statistical difference was found between methods (p=0.14). Parasite clearance time by qPCR was longer than by microscopy (14 days vs. 7 days), and longer clearance time was also seen with higher parasitemia (p<0.01). Interpretation of P. vivax parasitemia by qPCR in clinical studies conducted in endemic areas should be done with caution until a reliable laboratory test that clearly distinguishes relapses from reinfections is available.
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).