Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function

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Objective: To evaluate the relationship between uremic index (UI) and renal function measured by creatinine clearance (CrCl) in persons with normal renal function and in those with chronic renal failure (CRF), as well as to compare the renal function extrapolated from serum creatinine and that calcu...

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Detalles Bibliográficos
Autores: Cruz Llanos, Luis Enrique, Cieza Zevallos, Javier Antonio
Formato: artículo
Fecha de Publicación:2022
Institución:Universidad Peruana Cayetano Heredia
Repositorio:Revistas - Universidad Peruana Cayetano Heredia
Lenguaje:español
OAI Identifier:oai:revistas.upch.edu.pe:article/4118
Enlace del recurso:https://revistas.upch.edu.pe/index.php/RMH/article/view/4118
Nivel de acceso:acceso abierto
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spelling Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal functionRelación entre el índice urémico y la función renal en pacientes con enfermedad renal crónica y en personas sanasCruz Llanos, Luis EnriqueCieza Zevallos, Javier AntonioObjective: To evaluate the relationship between uremic index (UI) and renal function measured by creatinine clearance (CrCl) in persons with normal renal function and in those with chronic renal failure (CRF), as well as to compare the renal function extrapolated from serum creatinine and that calculated with equations internationally recommended. Methods: A cross sectional study was conducted including patients attended in outpatient clinics at Hospital Cayetano Heredia in Lima from June 2018 to June 2019. Pearson’s correlation between UI and CrCl was calculated; comparison of means of UI, serum creatinine and standard equations was done by ANOVA and eta square. Results: the overall UI was 4.37 ± 4.99 mg/dl and correlated linearly with CrCl (r=-0.74, p=0.000). The UI and the log UI were significantly more predictive of CrCl than serum creatinine and the international equations used. The UI correlated significantly with serum potassium than serum creatinine. Conclusions: The UI is a good indicator of the metabolic and nutritional status in persons with normal renal function and with CRF and reflects more accurately the CrCl.Objetivo: Evaluar la relación entre el índice urémico (IU) y la función renal medida por el aclaramiento de creatinina (ClCr) en personas sanas y en pacientes con enfermedad renal crónica (ERC); asimismo, comparar con la función renal extrapolada según la creatinina sérica y la calculada por algunas fórmulas recomendadas en la literatura internacional. Material y métodos: Estudio transversal, de correlación, analítico y observacional. Se incluyeron pacientes atendidos de forma ambulatoria en el Hospital Cayetano Heredia, Lima, Perú entre junio del 2018 y junio del 2019. Se realizó correlación de Pearson entre el IU y el ClCr; para la comparación de las medias del IU, creatinina sérica y las fórmulas estandarizadas en función al ClCr estratificado se utilizó el test de ANOVA y el eta cuadrado. Resultados: El IU de la población fue 4,37 ± 4,99 mg/dl y presentó correlación lineal cuadrática estadísticamente significativa con el ClCr (r=-0,74, p=0,000). Asimismo, el IU y el Log IU mostraron un valor predictivo del ClCr superior a la creatinina sérica y a las diversas fórmulas recomendadas en la literatura. El IU presentó correlación significativa con el potasio sérico y su fracción excretoria de forma relevante en comparación con la creatinina sérica. Conclusiones: El IU es un indicador del estado metabólico y nutricional que refleja el ClCr con una precisión estadísticamente significativa en la persona sana y en el paciente con distintos grados de ERC. Además, traduce aspectos relevantes de la función tubular renal.Universidad Peruana Cayetano Heredia2022-01-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed articleArtículo evaluado por paresapplication/pdfhttps://revistas.upch.edu.pe/index.php/RMH/article/view/411810.20453/rmh.v32i4.4118Revista Médica Herediana; Vol. 32 No. 4 (2021): October-December; 216-223Revista Médica Herediana; Vol. 32 Núm. 4 (2021): Octubre-Diciembre; 216-223Revista Medica Herediana; v. 32 n. 4 (2021): Octubre-Diciembre; 216-2231729-214X1018-130Xreponame:Revistas - Universidad Peruana Cayetano Herediainstname:Universidad Peruana Cayetano Herediainstacron:UPCHspahttps://revistas.upch.edu.pe/index.php/RMH/article/view/4118/4653Derechos de autor 2022 Luis Enrique Cruz Llanos, Javier Antonio Cieza Zevallosinfo:eu-repo/semantics/openAccessoai:revistas.upch.edu.pe:article/41182022-01-19T17:04:08Z
dc.title.none.fl_str_mv Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
Relación entre el índice urémico y la función renal en pacientes con enfermedad renal crónica y en personas sanas
title Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
spellingShingle Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
Cruz Llanos, Luis Enrique
title_short Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
title_full Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
title_fullStr Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
title_full_unstemmed Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
title_sort Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
dc.creator.none.fl_str_mv Cruz Llanos, Luis Enrique
Cieza Zevallos, Javier Antonio
author Cruz Llanos, Luis Enrique
author_facet Cruz Llanos, Luis Enrique
Cieza Zevallos, Javier Antonio
author_role author
author2 Cieza Zevallos, Javier Antonio
author2_role author
description Objective: To evaluate the relationship between uremic index (UI) and renal function measured by creatinine clearance (CrCl) in persons with normal renal function and in those with chronic renal failure (CRF), as well as to compare the renal function extrapolated from serum creatinine and that calculated with equations internationally recommended. Methods: A cross sectional study was conducted including patients attended in outpatient clinics at Hospital Cayetano Heredia in Lima from June 2018 to June 2019. Pearson’s correlation between UI and CrCl was calculated; comparison of means of UI, serum creatinine and standard equations was done by ANOVA and eta square. Results: the overall UI was 4.37 ± 4.99 mg/dl and correlated linearly with CrCl (r=-0.74, p=0.000). The UI and the log UI were significantly more predictive of CrCl than serum creatinine and the international equations used. The UI correlated significantly with serum potassium than serum creatinine. Conclusions: The UI is a good indicator of the metabolic and nutritional status in persons with normal renal function and with CRF and reflects more accurately the CrCl.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-19
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed article
Artículo evaluado por pares
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://revistas.upch.edu.pe/index.php/RMH/article/view/4118
10.20453/rmh.v32i4.4118
url https://revistas.upch.edu.pe/index.php/RMH/article/view/4118
identifier_str_mv 10.20453/rmh.v32i4.4118
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://revistas.upch.edu.pe/index.php/RMH/article/view/4118/4653
dc.rights.none.fl_str_mv Derechos de autor 2022 Luis Enrique Cruz Llanos, Javier Antonio Cieza Zevallos
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2022 Luis Enrique Cruz Llanos, Javier Antonio Cieza Zevallos
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Universidad Peruana Cayetano Heredia
publisher.none.fl_str_mv Universidad Peruana Cayetano Heredia
dc.source.none.fl_str_mv Revista Médica Herediana; Vol. 32 No. 4 (2021): October-December; 216-223
Revista Médica Herediana; Vol. 32 Núm. 4 (2021): Octubre-Diciembre; 216-223
Revista Medica Herediana; v. 32 n. 4 (2021): Octubre-Diciembre; 216-223
1729-214X
1018-130X
reponame:Revistas - Universidad Peruana Cayetano Heredia
instname:Universidad Peruana Cayetano Heredia
instacron:UPCH
instname_str Universidad Peruana Cayetano Heredia
instacron_str UPCH
institution UPCH
reponame_str Revistas - Universidad Peruana Cayetano Heredia
collection Revistas - Universidad Peruana Cayetano Heredia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 12.825565
Relationship between uremic index and renal function in patients with chronic renal failure and in those with normal renal function
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