Factors associated with primary multidrug-resistant tuberculosis in patients from Callao, Peru

• Autores: Ávalos Rodríguez, Ana Cecilia, Imán Izquierdo, Fernando Jean Carlos, Virú Loza, Manuel André, Cabrera Rivero, José, Zárate Robles, Anthony Edgar, Meza Monterrey, Mariela Cecibet, Ñaupari Meza, Brenner Alberto, Figueroa Bravo, Wendy Teoana, Cajas Socualaya, Mirella Kristal, Castro Trujillo, Hugo Paul, Zapata Susanívar, Talía Minerva
• Formato: artículo
• Fecha de Publicación: 2014
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/9775
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/9775
• Nivel de acceso: acceso abierto
• Materia: Tuberculosis; multidrug- resistance; risk factors; Peru.; multidrogorresistente; factores de riesgo; Perú.

Introduction: Lima and Callao are high risk areas for tuberculosis active transmission in Peru. Multidrug-resistant tuberculosis represents 5.54% of the new cases of pulmonary tuberculosis (primary MDR-TB) in Lima and Callao. Involved risk factors have not been studied in patients from Callao. Objectives: To determine risk factors for primary MDR-TB in patients attending health care facilities in Callao during 2009-2010. Design: Case-control study. Setting: Health care facilities from Callao. Participants: Twenty nine primary MDR-TB patients and 37 drug-sensitive TB patients were studied through assessment of the Tuberculosis Control Program Registries and healthcare facilities’ clinical records. Interventions: Information was obtained from secondary sources. Odds-ratios were calculated by bivariate analysis. Logistic regression models were used to calculate multivariate odd-ratios. Main outcome measures: Risk factors for primary MDR-TB. Results: Prior contact with a MDR-TB or XDR-TB patient was a significant risk factor (OR: 5.56; 95%CI: 1.05-29.27) in bivariate analysis; the same was found in multivariate analysis (OR: 14.56; 95%CI: 1.52–139.54). Being 40 or more years old was a significant protective factor in multivariate analysis (OR: 0.94; 95% CI: 0.90–0.99). Conclusions: Previous contact with a MDR-TB or XDR-TB patient was a risk factor, and being 40 or more years old was a protective factor for primary MDR-TB in Callao patients studied.