Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies
Descripción del Articulo
The aim of the present study was to study the expression of laminin 5 in equine foot biopsies precultured with venom of Bothrops diporus by histopathology and immunohistochemistry against untreated controls. The basal membranes of the laminae of the biopsies, as well as those of the interlamellar ar...
| Autores: | , , , , |
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| Formato: | artículo |
| Fecha de Publicación: | 2018 |
| Institución: | Universidad Nacional Mayor de San Marcos |
| Repositorio: | Revistas - Universidad Nacional Mayor de San Marcos |
| Lenguaje: | español |
| OAI Identifier: | oai:ojs.csi.unmsm:article/14524 |
| Enlace del recurso: | https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/14524 |
| Nivel de acceso: | acceso abierto |
| Materia: | laminina 5 expresión biopsia veneno cultivo pie equino laminin 5 expression biopsy venom culture equine foot |
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Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsiesEfecto del veneno de Bothrops diporus sobre la expresión de laminina 5 en biopsias de pie equinoTeibler, PamelaAguirre, MaríaStoyanoff, TaniaNúñez, SandraMaruñak, Silvanalaminina 5expresiónbiopsiavenenocultivopie equinolaminin 5expressionbiopsyvenomcultureequine footThe aim of the present study was to study the expression of laminin 5 in equine foot biopsies precultured with venom of Bothrops diporus by histopathology and immunohistochemistry against untreated controls. The basal membranes of the laminae of the biopsies, as well as those of the interlamellar arterioles and veins, showed intense immunostaining of laminin 5 (L-5) in the control cultures; however, it was significantly lower in pre-cultured biopsies with the B. diporus venom concomitantly with the disruption of the typical laminar plate histoarchitecture. These results describe for the first time the normo-localization of L-5 in equine foot biopsies and the effect of the metalloproteinases, components of B. diporus venoms, both in the lamellar integrity and in the components of the vascularization.El objetivo del presente trabajo fue estudiar la expresión de laminina 5 en cortes de biopsias de pie equino precultivados con veneno de serpiente Bothrops diporus por histopatología e inmunohistoquímica contra controles no tratados. Las membranas basales de las láminas de las biopsias, así como las de las arteriolas y venas interlamelares evidenciaron intensa inmunomarcación de laminina 5 (L-5) en los cultivos controles; sin embargo, fue significativamente menor en las biopsias precultivadas con el veneno de B. diporus concomitantemente con la disrupción de la histoarquitectura típica de las laminillas. Estos resultados describen por primera vez la normo-localización de L-5 en biopsias de pie equino y el efecto de las metaloproteinasas, componentes de los venenos de B. diporus, tanto en la integridad lamelar como en los componentes de la vascularización.Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria2018-05-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmlhttps://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/1452410.15381/rivep.v29i2.14524Revista de Investigaciones Veterinarias del Perú; Vol. 29 Núm. 2 (2018); 462-471Revista de Investigaciones Veterinarias del Perú; Vol. 29 No. 2 (2018); 462-4711682-34191609-9117reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/14524/12824https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/14524/13944Derechos de autor 2018 Pamela Teibler, María Aguirre, Tania Stoyanoff, Sandra Núñez, Silvana Maruñakhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessoai:ojs.csi.unmsm:article/145242018-12-21T09:58:48Z |
| dc.title.none.fl_str_mv |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies Efecto del veneno de Bothrops diporus sobre la expresión de laminina 5 en biopsias de pie equino |
| title |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies |
| spellingShingle |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies Teibler, Pamela laminina 5 expresión biopsia veneno cultivo pie equino laminin 5 expression biopsy venom culture equine foot |
| title_short |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies |
| title_full |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies |
| title_fullStr |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies |
| title_full_unstemmed |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies |
| title_sort |
Effect of the venom of Bothrops diporus on the expression of Laminine 5 in equine foot biopsies |
| dc.creator.none.fl_str_mv |
Teibler, Pamela Aguirre, María Stoyanoff, Tania Núñez, Sandra Maruñak, Silvana |
| author |
Teibler, Pamela |
| author_facet |
Teibler, Pamela Aguirre, María Stoyanoff, Tania Núñez, Sandra Maruñak, Silvana |
| author_role |
author |
| author2 |
Aguirre, María Stoyanoff, Tania Núñez, Sandra Maruñak, Silvana |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
laminina 5 expresión biopsia veneno cultivo pie equino laminin 5 expression biopsy venom culture equine foot |
| topic |
laminina 5 expresión biopsia veneno cultivo pie equino laminin 5 expression biopsy venom culture equine foot |
| description |
The aim of the present study was to study the expression of laminin 5 in equine foot biopsies precultured with venom of Bothrops diporus by histopathology and immunohistochemistry against untreated controls. The basal membranes of the laminae of the biopsies, as well as those of the interlamellar arterioles and veins, showed intense immunostaining of laminin 5 (L-5) in the control cultures; however, it was significantly lower in pre-cultured biopsies with the B. diporus venom concomitantly with the disruption of the typical laminar plate histoarchitecture. These results describe for the first time the normo-localization of L-5 in equine foot biopsies and the effect of the metalloproteinases, components of B. diporus venoms, both in the lamellar integrity and in the components of the vascularization. |
| publishDate |
2018 |
| dc.date.none.fl_str_mv |
2018-05-31 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/14524 10.15381/rivep.v29i2.14524 |
| url |
https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/14524 |
| identifier_str_mv |
10.15381/rivep.v29i2.14524 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/14524/12824 https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/14524/13944 |
| dc.rights.none.fl_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf text/html |
| dc.publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria |
| publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Medicina Veterinaria |
| dc.source.none.fl_str_mv |
Revista de Investigaciones Veterinarias del Perú; Vol. 29 Núm. 2 (2018); 462-471 Revista de Investigaciones Veterinarias del Perú; Vol. 29 No. 2 (2018); 462-471 1682-3419 1609-9117 reponame:Revistas - Universidad Nacional Mayor de San Marcos instname:Universidad Nacional Mayor de San Marcos instacron:UNMSM |
| instname_str |
Universidad Nacional Mayor de San Marcos |
| instacron_str |
UNMSM |
| institution |
UNMSM |
| reponame_str |
Revistas - Universidad Nacional Mayor de San Marcos |
| collection |
Revistas - Universidad Nacional Mayor de San Marcos |
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13.905881 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
