Fatal outcome in coinfection between SARS-CoV-2 and dengue

• Autores: Ramírez, Juan, Noreña-Buitrón, Lizeth, Estela-Zape, Jose
• Formato: artículo
• Fecha de Publicación: 2023
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/26855
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/26855
• Nivel de acceso: acceso abierto
• Materia: COVID-19; Dengue; Coinfección; Inmunidad; Coinfection; Immunity

COVID-19, a result of SARS-CoV-2 infection, is characterized by a primary impact on the alveolar cells of the respiratory system. However, the possibility of co-infection with dengue virus (DENV) has been documented, triggering a severe systemic inflammatory response. This heightened inflammatory response leads to a substantial release of viral RNA into the cellular cytoplasm, which amplifies the viral load and aggravates lung damage, causing multiple organ dysfunction. In the case of DENV, the infection induces a cytokine storm that increases capillary permeability, resulting in plasma leakage. The present report aims to describe a case of an adult male patient with COVID-19 and dengue co-infection who had a fatal outcome.