Histopathological and immunohistochemical (IHC) diagnosis of non-Hodgkin lymphoma (LNH) in a female canine

• Autores: Losada, Martha, Poche, Alba, Velásquez, Victoria, Sanchez, Víctor
• Formato: artículo
• Fecha de Publicación: 2020
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/17939
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/veterinaria/article/view/17939
• Nivel de acceso: acceso abierto
• Materia: large cells; biomarkers; CD3; canine; female; cervix; células grandes; biomarcadores; canino; hembra; cérvix

The clinical case of a 2-year-old female canine patient, French Poodle breed, who had presented three evident oestrous in a period of less than six months, according to the owner, is described. In the initial clinical examination, a patient with apoplexy signs was observed and in the examination of the genitourinary apparatus, abundant vaginal sero-bloody secretion was evident. The ultrasound study of the inguinal region reveals the presence of a non-specific rounded hyperechogenic structure with multiple oncogenic areas suggestive of pyometra. Cytology was performed by ultrasound-guided mass puncture that showed as a presumptive diagnosis of round cell neoplasia. An exploratory laparotomy is performed in which a mass of reddish colour in the cervix of 8 cm in diameter and 3 cm wide was evident. Histopathological study of the tumour mass sample gave a definitive diagnosis of malignant neoplasm of large cells consistent with intermediate grade non-Hodgkin lymphoma. The confrontation with CD3 biomarkers yielded a severe reactivity result with extensive multifocal distribution. Given the casuistic conditions, euthanasia was performed. The autopsy showed metastatic foci in the ribs.