Study of the mechanisms of CO2 fixation in Ehrlich ascites tumor

• Autor: Melgar Salmón, Ernesto
• Formato: artículo
• Fecha de Publicación: 1962
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/5998
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/5998
• Nivel de acceso: acceso abierto

We conducted the study of the mechanisms of CO2 fixation in the Ehrlich ascites tumor , with the following results : 1. Ribose -5-phosphate was a slight stimulatory effect of fixing C14O2 ; however, could not be isolated 3- phosphoglyceric radioactive conditions that favored its accumulation . Two . Using pyruvic acid as a substrate , the amount of binding was higher . The addition of TPNH to said attachment homogenates greatly increased . Three . Isolates organic acids , the increased incorporation of C14 was detected in the succinic and malic . April . The partially purified acetone extracts showed activity of malic enzyme . The above results allow us to conclude that in the Ehrlich ascites tumor , CO2 fixation is performed almost exclusively by the action of malic enzyme , there being no evidence that it occurs at the level of ribulose -1 ,5- diphosphate.