Advances in the diagnosis and treatment of iron deficiency and iron deficiency anemia

• Autores: Alvarado, Carlos S., Yanac-Avila, Rommel, Marron-Veria, Evelyn, Málaga-Zenteno, José, Adamkiewicz, Thomas V.
• Formato: artículo
• Fecha de Publicación: 2022
• Institución: Universidad Nacional Mayor de San Marcos
• Repositorio: Revistas - Universidad Nacional Mayor de San Marcos
• Lenguaje: español
• OAI Identifier: oai:ojs.csi.unmsm:article/21721
• Enlace del recurso: https://revistasinvestigacion.unmsm.edu.pe/index.php/anales/article/view/21721
• Nivel de acceso: acceso abierto
• Materia: Deficiencia de Hierro; Anemia Ferropénica; Diagnóstico; Tratamiento; Iron Deficiency; Anemia; Iron-Deficiency; Diagnosis; Therapeutics

Iron deficiency (ID) and iron deficiency anemia (IDA) are still major health problems worldwide, affecting especially preschool children and pregnant women. The objectives of this article are: a) To describe the laboratory tests for diagnosing IDA and the factors that may influence results of the serum ferritin and the other iron biomarkers ; b) To present advances in iron metabolism, i.e. the critical regulatory role of hepcidin in the absorption and utilization of iron ; c) To describe the impact this new knowledge has had in the design of clinical investigations comparing the absorption of iron following oral supplementation given in consecutive days vs. alternate days schedules; and, d) To describe the clinical situations in which intravenous iron is indicated as secondary or first-line treatment. The concepts expressed and the suggestions made in this article are based on updated literature and the clinical experience of the authors.