Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae)
Descripción del Articulo
The myotoxin isolated from the venom of the snake Bothrops brazili has been studied in its mode of action. In the first hour of activity the myotoxin injected in the gastrocnemius muscle of white mice, induces the release of creatine kinase and lactate dehydrogenase, while by PAGE-SDS, it is shown t...
| Autores: | , , |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2002 |
| Institución: | Universidad Nacional Mayor de San Marcos |
| Repositorio: | Revistas - Universidad Nacional Mayor de San Marcos |
| Lenguaje: | español |
| OAI Identifier: | oai:ojs.csi.unmsm:article/2526 |
| Enlace del recurso: | https://revistasinvestigacion.unmsm.edu.pe/index.php/rpb/article/view/2526 |
| Nivel de acceso: | acceso abierto |
| Materia: | miotoxina Bothrops brazili veneno de serpiente mionecrosis myotoxin snake venom myonecrosis |
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Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae)Acción de la miotoxina del veneno de Bothrops brazili Hoge, 1953 (Ophidia: Viperidae)Pantigoso, CarmenEscobar, EnriqueYarlequé, ArmandomiotoxinaBothrops braziliveneno de serpientemionecrosismyotoxinBothrops brazilisnake venommyonecrosisThe myotoxin isolated from the venom of the snake Bothrops brazili has been studied in its mode of action. In the first hour of activity the myotoxin injected in the gastrocnemius muscle of white mice, induces the release of creatine kinase and lactate dehydrogenase, while by PAGE-SDS, it is shown that the incubation of miotoxin with isolated gastrocnemius muscle releases other proteins from this tissue. Moreover myotoxin produces hipercontraction, delta lesions and increases the concentration of intramuscular calcium “in vivo” and “in vitro”, which does not depend on extracellular calcium entry through dyhidropyridine receptors. This increase of calcium would explain the hipercontraction observed. Also it could trigger the activation of endogenous proteases and lipases, which would lead to muscle necrosis.Se ha estudiado el modo de acción de la miotoxina aislada del veneno de la serpiente Bothrops brazili. La inoculación de la miotoxina en el músculo gastrocnemius de ratones albinos produce durante la primera hora de acción la liberación de creatina kinasa y lactato deshidrogenasa, mientras que por PAGE-SDS, se revela que la incubación de la miotoxina con músculo gastrocnemius aislado, produce además la liberación de otras proteínas musculares. Asimismo, la miotoxina produce hipercontracción, lesiones delta e incrementa los niveles de calcio intramuscular, tanto in vivo como in vitro, lo cual no depende del ingreso de calcio extracelular vía receptores de dihidropiridina. Este incremento de calcio explicaría la hipercontracción observada y podría generar la activación de proteasas y lipasas endógenas dependientes de calcio, que conducirían a la necrosis muscular.Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas2002-12-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revistasinvestigacion.unmsm.edu.pe/index.php/rpb/article/view/252610.15381/rpb.v9i2.2526Revista Peruana de Biología; Vol. 9 Núm. 2 (2002); 74-83Revista Peruana de Biología; Vol. 9 No. 2 (2002); 74-831727-99331561-0837reponame:Revistas - Universidad Nacional Mayor de San Marcosinstname:Universidad Nacional Mayor de San Marcosinstacron:UNMSMspahttps://revistasinvestigacion.unmsm.edu.pe/index.php/rpb/article/view/2526/2219Derechos de autor 2002 Carmen Pantigoso, Enrique Escobar, Armando Yarlequéhttps://creativecommons.org/licenses/by-nc-sa/4.0info:eu-repo/semantics/openAccessoai:ojs.csi.unmsm:article/25262020-05-25T18:16:08Z |
| dc.title.none.fl_str_mv |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) Acción de la miotoxina del veneno de Bothrops brazili Hoge, 1953 (Ophidia: Viperidae) |
| title |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) |
| spellingShingle |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) Pantigoso, Carmen miotoxina Bothrops brazili veneno de serpiente mionecrosis myotoxin Bothrops brazili snake venom myonecrosis |
| title_short |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) |
| title_full |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) |
| title_fullStr |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) |
| title_full_unstemmed |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) |
| title_sort |
Action of the myotoxin from Bothrops brazili Hoge, 1953 snake venom (Ophidia: Viperidae) |
| dc.creator.none.fl_str_mv |
Pantigoso, Carmen Escobar, Enrique Yarlequé, Armando |
| author |
Pantigoso, Carmen |
| author_facet |
Pantigoso, Carmen Escobar, Enrique Yarlequé, Armando |
| author_role |
author |
| author2 |
Escobar, Enrique Yarlequé, Armando |
| author2_role |
author author |
| dc.subject.none.fl_str_mv |
miotoxina Bothrops brazili veneno de serpiente mionecrosis myotoxin Bothrops brazili snake venom myonecrosis |
| topic |
miotoxina Bothrops brazili veneno de serpiente mionecrosis myotoxin Bothrops brazili snake venom myonecrosis |
| description |
The myotoxin isolated from the venom of the snake Bothrops brazili has been studied in its mode of action. In the first hour of activity the myotoxin injected in the gastrocnemius muscle of white mice, induces the release of creatine kinase and lactate dehydrogenase, while by PAGE-SDS, it is shown that the incubation of miotoxin with isolated gastrocnemius muscle releases other proteins from this tissue. Moreover myotoxin produces hipercontraction, delta lesions and increases the concentration of intramuscular calcium “in vivo” and “in vitro”, which does not depend on extracellular calcium entry through dyhidropyridine receptors. This increase of calcium would explain the hipercontraction observed. Also it could trigger the activation of endogenous proteases and lipases, which would lead to muscle necrosis. |
| publishDate |
2002 |
| dc.date.none.fl_str_mv |
2002-12-30 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/rpb/article/view/2526 10.15381/rpb.v9i2.2526 |
| url |
https://revistasinvestigacion.unmsm.edu.pe/index.php/rpb/article/view/2526 |
| identifier_str_mv |
10.15381/rpb.v9i2.2526 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://revistasinvestigacion.unmsm.edu.pe/index.php/rpb/article/view/2526/2219 |
| dc.rights.none.fl_str_mv |
Derechos de autor 2002 Carmen Pantigoso, Enrique Escobar, Armando Yarlequé https://creativecommons.org/licenses/by-nc-sa/4.0 info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Derechos de autor 2002 Carmen Pantigoso, Enrique Escobar, Armando Yarlequé https://creativecommons.org/licenses/by-nc-sa/4.0 |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas |
| publisher.none.fl_str_mv |
Universidad Nacional Mayor de San Marcos, Facultad de Ciencias Biológicas |
| dc.source.none.fl_str_mv |
Revista Peruana de Biología; Vol. 9 Núm. 2 (2002); 74-83 Revista Peruana de Biología; Vol. 9 No. 2 (2002); 74-83 1727-9933 1561-0837 reponame:Revistas - Universidad Nacional Mayor de San Marcos instname:Universidad Nacional Mayor de San Marcos instacron:UNMSM |
| instname_str |
Universidad Nacional Mayor de San Marcos |
| instacron_str |
UNMSM |
| institution |
UNMSM |
| reponame_str |
Revistas - Universidad Nacional Mayor de San Marcos |
| collection |
Revistas - Universidad Nacional Mayor de San Marcos |
| repository.name.fl_str_mv |
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1795238309797036032 |
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13.947759 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
