Clinicopathological characteristics and body mass index in Uruguayan women with breast cancer from the Hospital de Clínicas

• Autores: Camejo, Natalia, Amarillo, Dahiana, Ceriani, Florencia, de León Manfrú, Lidia, De Olea, Florencia, Diaz, Mauricio, Donato, Franco, Suarez, Alexandra, Tamborindeguy, Rocio, Castillo, Cecilia, Krygier, Gabriel
• Formato: artículo
• Fecha de Publicación: 2023
• Institución: Universidad Nacional Hermilio Valdizan
• Repositorio: Revistas - Universidad Nacional Hermilio Valdizán
• Lenguaje: español
• OAI Identifier: oai:revistas.unheval.edu.pe:article/1824
• Enlace del recurso: http://revistas.unheval.edu.pe/index.php/repis/article/view/1824
• Nivel de acceso: acceso abierto
• Materia: breast neoplasms; body mass index; overweight; obesity; neoplasma de mama; índice de masa corporal; sobrepeso; obesidad

Objective. To describe the clinicopathological characteristics of breast cancer (BC) in overweight/obese women and their management in clinical practice, focusing on Uruguayan patients treated in the Oncology Department of Hospital de Clínicas. Materials and Methods. This was an observational, descriptive, retrospective, cross-sectional study that included patients diagnosed with BC at the aforementioned center from January 2020 to May 2022. We evaluated demographic variables, Body Mass Index (BMI), histological subtype, hormonal receptors, HER2/neu status, and received treatments. Statistical Tests: Descriptive statistics such as mean and standard deviation were utilized, along with analytical tests like chi-square and Student's t-test for independent samples. Descriptive: Mean and standard deviation for quantitative variables; frequencies for qualitative variables. Analytical: Chi-square for qualitative variables and Student's t-test for quantitative variables. Results. A total of 141 patients were included, 56% of whom were overweight/obese. The median age at diagnosis was similar for both groups: 58 vs. 58.8 years (p=0.762). Among overweight/obese patients, ductal carcinoma (p=0.005) and mastectomy (p=0.012) were more frequent, while luminal tumors showed no statistical significance. In contrast, patients with normal weight were more likely to have lobular carcinoma (p=0.043) and conservative surgery (p=0.012), but triple-negative tumors were not statistically significant. The proportion of patients experiencing recurrence was similar in both groups (p=0.48). Conclusions. In our study, overweight and obesity were not related to most of the characteristics of breast cancer, but they were associated with the histological type and the kind of surgical treatment. No significant differences were observed in the recurrence rate between the two groups of patients.