Hepatoprotective effect of hydroalcoholic extract of Desmodium molliculum (“manayupa”) in rats with hepatic intoxication induced by paracetamol

• Autor: Saucedo Estela, Pamela Yanina
• Formato: artículo
• Fecha de Publicación: 2019
• Institución: Universidad María Auxiliadora
• Repositorio: Agora
• Lenguaje: español
• OAI Identifier: oai:ojs2.revistaagora.com:article/103
• Enlace del recurso: https://revistaagora.com/index.php/cieUMA/article/view/103
• Nivel de acceso: acceso abierto
• Materia: hepatotoxicidad; paracetamol; Desmodium molliculum; hepatotoxicity

Objective: To determine the hepatoprotective effect of the hydroalcoholic extract of Desmodium molliculum (“manayupa”) at different concentrations (50, 500 and 800 mg/kg), and also to evaluate its active metabolites. Materials and Methods: Hydroalcoholic extract of D. molliculum was applied to Holtzman rats randomized into six groups (n = 5), which received the following treatments, for ten days, via peroral: groups I and II: physiological serum 10 mL/kg; group III: silymarin 100 mg/kg; Group IV: 50 mg/kg; group V: 500 mg/kg and group VI: 800 mg/kg of the hydroalcoholic extract. On the sixth day of treatment, rats from groups II to VI received paracetamol at 400 mg/kg perorally, with one hour difference from previous treatment, until complete ten days. Results: According to the doses administered, it was observed that the extract of 500 mg/kg and 800 mg/kg of the hydroalcoholic extract showed the largest hepatoprotective effect. Conclusions: The hydroalcoholic extract of Desmodium molliculum (“manayupa”) showed an hepatoprotective effect.