Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal

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OBJECTIVE: To determine estrogen plasmatic levels and clinical effects after oral and transdermal estrogen administration to postmenopausal women. MATERIAL AND METHODS: Prospective, longitudinal, deliberate intervention, sequential, crossed and simpleblinded study. Group 1 (n=22) consisted of two cy...

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Detalles Bibliográficos
Autor: Bellido B., Percy
Formato: artículo
Fecha de Publicación:2015
Institución:Sociedad Peruana de Obstetricia y Ginecología
Repositorio:Revista Peruana de Ginecología y Obstetricia
Lenguaje:español
OAI Identifier:oai:ojs.pkp.sfu.ca:article/629
Enlace del recurso:http://51.222.106.123/index.php/RPGO/article/view/629
Nivel de acceso:acceso abierto
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oai_identifier_str oai:ojs.pkp.sfu.ca:article/629
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network_name_str Revista Peruana de Ginecología y Obstetricia
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spelling Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermalConcentración plasmática de estrógenos en mujeres posmenopáusicas que reciben terapia estrogénica oral y transdérmicaBellido B., PercyOBJECTIVE: To determine estrogen plasmatic levels and clinical effects after oral and transdermal estrogen administration to postmenopausal women. MATERIAL AND METHODS: Prospective, longitudinal, deliberate intervention, sequential, crossed and simpleblinded study. Group 1 (n=22) consisted of two cycles of oral treatment and two cycles of transdermal. Group 2 (n=25), inverse sequence. Three estradiol measurements: basal, at 8 and 16 weeks. RESULTS: The estradiol (E2) plasmatic levels were greater in the oral therapy than in the transdermal; in both cases E2 did not return to basal levels after 7 days of treatment conclusion; the clinical improvement is independent of estrogen administration. CONCLUSION: Better levels are achieved with natural conjugated estrogens than with 17betaestradiol. The period without treatment after each cycle must be rol than 7 days.OBJETIVO: Determinar la concentración plasmática de estrógenos y efecto clínico luego de estrogenoterapia administrada en posmenopáusicas por vía oral y transdérmica. MATERIAL Y MÉTODOS: Estudio longitudinal prospectivo con intervención deliberada secuencial cruzado, simple ciego. Grupo 1 (n=22) dos ciclos de tratamiento oral y dos ciclos de tratamiento transdérmico; Grupo 2 (n=25) secuencia inversa. Tres determinaciones de estradiol: basal, a las 8 y 16 semanas. RESULTADOS: La concentración plasmática de estradiol (E2) fue mayor en administración oral que transdérmica; en ambos casos el E2 no retornó a cifras basales a los 7 días de concluido el tratamiento; la mejoría clínica fue independiente de la vía de administración de estrógenos. CONCLUSIÓN: Se logra mejor concentración plasmática con estrógenos conjugados naturales que con 17 beta estradiol; el periodo de reposo entre tratamiento debe ser mayor de 7 días.Sociedad Peruana de Obstetricia y Ginecología2015-05-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://51.222.106.123/index.php/RPGO/article/view/629The Peruvian Journal of Gynecology and Obstetrics ; Vol. 45 No. 1 (1999); 27-32Revista Peruana de Ginecología y Obstetricia; Vol. 45 Núm. 1 (1999); 27-322304-51322304-5124reponame:Revista Peruana de Ginecología y Obstetriciainstname:Sociedad Peruana de Obstetricia y Ginecologíainstacron:SPOGspahttp://51.222.106.123/index.php/RPGO/article/view/629/592info:eu-repo/semantics/openAccessoai:ojs.pkp.sfu.ca:article/6292015-07-28T22:08:01Z
dc.title.none.fl_str_mv Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
Concentración plasmática de estrógenos en mujeres posmenopáusicas que reciben terapia estrogénica oral y transdérmica
title Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
spellingShingle Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
Bellido B., Percy
title_short Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
title_full Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
title_fullStr Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
title_full_unstemmed Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
title_sort Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
dc.creator.none.fl_str_mv Bellido B., Percy
author Bellido B., Percy
author_facet Bellido B., Percy
author_role author
description OBJECTIVE: To determine estrogen plasmatic levels and clinical effects after oral and transdermal estrogen administration to postmenopausal women. MATERIAL AND METHODS: Prospective, longitudinal, deliberate intervention, sequential, crossed and simpleblinded study. Group 1 (n=22) consisted of two cycles of oral treatment and two cycles of transdermal. Group 2 (n=25), inverse sequence. Three estradiol measurements: basal, at 8 and 16 weeks. RESULTS: The estradiol (E2) plasmatic levels were greater in the oral therapy than in the transdermal; in both cases E2 did not return to basal levels after 7 days of treatment conclusion; the clinical improvement is independent of estrogen administration. CONCLUSION: Better levels are achieved with natural conjugated estrogens than with 17betaestradiol. The period without treatment after each cycle must be rol than 7 days.
publishDate 2015
dc.date.none.fl_str_mv 2015-05-19
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://51.222.106.123/index.php/RPGO/article/view/629
url http://51.222.106.123/index.php/RPGO/article/view/629
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://51.222.106.123/index.php/RPGO/article/view/629/592
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Peruana de Obstetricia y Ginecología
publisher.none.fl_str_mv Sociedad Peruana de Obstetricia y Ginecología
dc.source.none.fl_str_mv The Peruvian Journal of Gynecology and Obstetrics ; Vol. 45 No. 1 (1999); 27-32
Revista Peruana de Ginecología y Obstetricia; Vol. 45 Núm. 1 (1999); 27-32
2304-5132
2304-5124
reponame:Revista Peruana de Ginecología y Obstetricia
instname:Sociedad Peruana de Obstetricia y Ginecología
instacron:SPOG
instname_str Sociedad Peruana de Obstetricia y Ginecología
instacron_str SPOG
institution SPOG
reponame_str Revista Peruana de Ginecología y Obstetricia
collection Revista Peruana de Ginecología y Obstetricia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 13.361153
Plasma concentration of estrogen in postmenopausal women receiving oral estrogen therapy and transdermal
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