P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case

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Introduction: Uterine cervix atrophic changes in postmenopausic women can mimic premalignant lesions, difficulting colposcopy and citopathology diagnosis. Immunohistochemical detection of p16INK4a could be useful as a diagnostic tool to differentiate between these changes. However, clinical evidence...

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Detalles Bibliográficos
Autores: Barrios, Lía, Borre, Orlando, Contreras, Eusebio
Formato: artículo
Fecha de Publicación:2014
Institución:Sociedad Peruana de Obstetricia y Ginecología
Repositorio:Revista Peruana de Ginecología y Obstetricia
Lenguaje:español
OAI Identifier:oai:ojs.pkp.sfu.ca:article/99
Enlace del recurso:http://51.222.106.123/index.php/RPGO/article/view/99
Nivel de acceso:acceso abierto
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spelling P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a caseP16INK4A en el diagnóstico diferencial entre atrofia cervicouterina y neoplasia intraepitelial cervical de alto grado (NIC III): reporte de casoBarrios, LíaBorre, OrlandoContreras, EusebioIntroduction: Uterine cervix atrophic changes in postmenopausic women can mimic premalignant lesions, difficulting colposcopy and citopathology diagnosis. Immunohistochemical detection of p16INK4a could be useful as a diagnostic tool to differentiate between these changes. However, clinical evidence must be provided in order to accept this technique. Case report: Postmenopausic patient with insatisfactory colposcopy and cyto-hystopathology findings suggestive but not conclusive of high grade cervical intraepithelial neoplasia. p16INK4a immunohistochemical detection was negative and hystology of diagnostic/therapeutic conization did not find intraepithelial lesion or malignancy. This case is a contribution favouring p16INK4a as a differential biomarker between atrophic and premalignant changes in order to avoid unnecessary interventions. Both patient’s informed consent and Universidad de Cartagena and E.S.E. Clinica “Maternidad Rafael Calvo” scientific subdirection institutional consent were obtained for the writing of this presentation.Introducción: En pacientes posmenopáusicas los cambios atróficos del cérvix dificultan el diagnóstico colposcópico y cito-histológico, pues pueden simular lesiones premalignas, por lo cual, la detección inmunohistoquimica de p16INK4a sería útil como herramienta diagnóstica diferencial entre estos cambios; sin embargo, es necesario aportar evidencias desde la perspectiva clínica. Caso clínico: Paciente posmenopáusica con colposcopia insatisfactoria y hallazgos cito-histológicos sugestivos pero no conclusivos de neoplasia intraepitelial cervical de alto grado (NIC III). La detección inmunohistoquímica de p16INK4a fue negativa. El estudio histológico de la conización diagnóstica/terapéutica no reportó lesión intraepitelial o maligna. Este caso permite aportar evidencia a favor del p16INK4a como biomarcador diferencial entre cambios atróficos y premalignos, con lo cual se podrían evitar intervenciones innecesarias. Para el desarrollo del manuscrito se contó con consentimiento informado de la paciente objeto de estudio y consentimiento institucional de la Universidad de Cartagena y la subdirección científica de la E.S.E. Clínica “Maternidad Rafael Calvo”. Sociedad Peruana de Obstetricia y Ginecología2014-02-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://51.222.106.123/index.php/RPGO/article/view/99The Peruvian Journal of Gynecology and Obstetrics ; Vol. 58 No. 1 (2012); 51-53Revista Peruana de Ginecología y Obstetricia; Vol. 58 Núm. 1 (2012); 51-532304-51322304-5124reponame:Revista Peruana de Ginecología y Obstetriciainstname:Sociedad Peruana de Obstetricia y Ginecologíainstacron:SPOGspahttp://51.222.106.123/index.php/RPGO/article/view/99/90info:eu-repo/semantics/openAccessoai:ojs.pkp.sfu.ca:article/992015-08-05T11:21:20Z
dc.title.none.fl_str_mv P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
P16INK4A en el diagnóstico diferencial entre atrofia cervicouterina y neoplasia intraepitelial cervical de alto grado (NIC III): reporte de caso
title P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
spellingShingle P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
Barrios, Lía
title_short P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
title_full P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
title_fullStr P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
title_full_unstemmed P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
title_sort P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
dc.creator.none.fl_str_mv Barrios, Lía
Borre, Orlando
Contreras, Eusebio
author Barrios, Lía
author_facet Barrios, Lía
Borre, Orlando
Contreras, Eusebio
author_role author
author2 Borre, Orlando
Contreras, Eusebio
author2_role author
author
description Introduction: Uterine cervix atrophic changes in postmenopausic women can mimic premalignant lesions, difficulting colposcopy and citopathology diagnosis. Immunohistochemical detection of p16INK4a could be useful as a diagnostic tool to differentiate between these changes. However, clinical evidence must be provided in order to accept this technique. Case report: Postmenopausic patient with insatisfactory colposcopy and cyto-hystopathology findings suggestive but not conclusive of high grade cervical intraepithelial neoplasia. p16INK4a immunohistochemical detection was negative and hystology of diagnostic/therapeutic conization did not find intraepithelial lesion or malignancy. This case is a contribution favouring p16INK4a as a differential biomarker between atrophic and premalignant changes in order to avoid unnecessary interventions. Both patient’s informed consent and Universidad de Cartagena and E.S.E. Clinica “Maternidad Rafael Calvo” scientific subdirection institutional consent were obtained for the writing of this presentation.
publishDate 2014
dc.date.none.fl_str_mv 2014-02-16
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://51.222.106.123/index.php/RPGO/article/view/99
url http://51.222.106.123/index.php/RPGO/article/view/99
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv http://51.222.106.123/index.php/RPGO/article/view/99/90
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Sociedad Peruana de Obstetricia y Ginecología
publisher.none.fl_str_mv Sociedad Peruana de Obstetricia y Ginecología
dc.source.none.fl_str_mv The Peruvian Journal of Gynecology and Obstetrics ; Vol. 58 No. 1 (2012); 51-53
Revista Peruana de Ginecología y Obstetricia; Vol. 58 Núm. 1 (2012); 51-53
2304-5132
2304-5124
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instacron:SPOG
instname_str Sociedad Peruana de Obstetricia y Ginecología
instacron_str SPOG
institution SPOG
reponame_str Revista Peruana de Ginecología y Obstetricia
collection Revista Peruana de Ginecología y Obstetricia
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P16INK4A in the differential diagnosis between cervical atrophy and high grade cervical intraepithelial neoplasia (CIN III): report of a case
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