Paget’s bone disease: polyostotic presentation in a patient with cancer of the uterine cervix

• Autores: Bojórquez-Castillo, Héctor, Trujillo-Aguirre, María de Lourdes, Tarco-Virto, Anita, Luis Paz-Ibarra, José
• Formato: artículo
• Fecha de Publicación: 2019
• Institución: Sociedad Peruana de Medicina Interna
• Repositorio: Revista de la Sociedad Peruana de Medicina Interna
• Lenguaje: español
• OAI Identifier: oai:medicinainterna.net.pe:article/17
• Enlace del recurso: https://revistamedicinainterna.net/index.php/spmi/article/view/17
• Nivel de acceso: acceso abierto
• Materia: Fosfatasa alcalina; enfermedad de Paget ósea; dolor óseo; bisfosfonatos; Alkaline phosphatase; Paget's bone disease; bone pain, bisphosphonates

A 65-year-old female patient with a history of malignant cervical neoplasia and trigeminal neuralgia presents a two-year history of intermittent chronic pain in the lumbar region and left hip. On the outpatient follow-up, a radiographic study of the hip showed a sclerous bone lesion in the left iliac wing and an alkaline phosphatase activity of 225 U/L, suggestive of Paget's disease of the bone. She was hospitalized for study by bone biopsy because of the possibility of bone metastasis. The bone survey, total body multi-slice spiral CT and bone scintigraphy showed similar lesions in right lower jaw and spine. Bisphosphonates was administered with significantly improving of bone and facial pain.