SIFILIS CONGENITA: REPORTE DE CASO

• Autores: Noel Peñafiel, Edgard, Hurtado Bocanegra, Mayra, Hermitaño Faustino, Yanely Medalit
• Formato: artículo
• Fecha de Publicación: 2025
• Institución: Instituto Nacional Materno Perinatal
• Repositorio: Revista Peruana de Investigación Materno Perinatal
• Lenguaje: español
• OAI Identifier: oai:investigacionmaternoperinatal.inmp.gob.pe:article/513
• Enlace del recurso: https://investigacionmaternoperinatal.inmp.gob.pe/index.php/rpinmp/article/view/513
• Nivel de acceso: acceso abierto
• Materia: Congenital syphilis; Premature; Prenatal screening; Congenital infections; Maternal and child health; Socioeconomic factors; Sífilis congénita; Recién nacido prematuro; Tamizaje prenatal; Enfermedades congénitas; Salud materno-infantil; Factores socioeconómicos

We report the case of a preterm newborn at 35 weeks of gestation diagnosed with congenital syphilis, born to an adolescent mother without prenatal care and with incomplete treatment for syphilis. The neonate presented with severe respiratory distress, marked direct cholestasis, thrombocytopenia, coagulopathy, and early hepatic dysfunction. Management included advanced resuscitation, a 14-day course of intravenous penicillin G, respiratory support, transfusions, and ursodeoxycholic acid. Bilateral periostitis, persistent hepatomegaly, and ocular infection by Enterobacter cloacae were documented. The clinical course was favorable, with respiratory stabilization, neurological improvement, and progressive weight gain, allowing discharge on day 16 with multidisciplinary follow-up. This case represents a severe and uncommon presentation of congenital syphilis, associated with significant clinical and social risk factors. The combination of multiorgan involvement, lack of prenatal screening, and maternal vulnerability highlights the urgent need for comprehensive strategies for prevention, early diagnosis, and specialized follow-up to reduce neonatal morbidity and mortality.