Hypoglycemic effect of aqueous and ethanol extracts of Psidium guajava L. (guajava) in alloxan-induced diabetic rats

• Autores: Inocente-Camones, Miguel Angel, Guija-Poma, Emilio, Zarzosa-Norabuena, Edwin, Loja Herrera, Berta, Ponce-Pardo, John Eloy
• Formato: artículo
• Fecha de Publicación: 2015
• Institución: Universidad de San Martín de Porres
• Repositorio: Horizonte médico
• Lenguaje: español
• OAI Identifier: oai:horizontemedico.usmp.edu.pe:article/279
• Enlace del recurso: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/279
• Nivel de acceso: acceso abierto
• Materia: Psidium guajava L.; Diabetes mellitus; Antidiabetic; Alloxan; Blood glucose; Antidiabéticos; Aloxano; Glucosa sanguínea

Objective: To evaluate antidiabetic activity of water and ethanol extracts from Psidium guajava L. leaves in alloxan-induced diabetic rats. Material and Methods: Hyperglycemia was induced in albino rats by administering alloxan monohydrate (100 mg/kg i.p.). Water extract at a dose of 250 mg/kg was administered at a single dose, while ethanol extracts at doses of 250 and 500 mg/kg were also administered at a single dose. Blood glucose was determined two hours after administering the extracts. Results: The addition of water and ethanol extracts of Psidium guajava L. tended to decrease the blood glucose concentration. The water extract at a concentration of 250 mg/kg was found to be more potent than ethanol extracts with the lowest mean glucose concentration of 86.67 mg/dL two hours after it was administered. The effect of ethanol extract was only observed at the concentration of 500 mg/kg with a slight decrease in blood glucose. Conclusion: This study indicated a significant antidiabetic activity of water extract of Psidium guajava L. in alloxan induced diabetic rats.