Drug reaction with eosinophilia and systemic symptoms syndrome caused by extended-release carbamazepine: a case report

• Autores: Gamarra Osorio, Elman Rolando, Arzani Lezcano, Deborah Ximena, Burgos Garcia, Olga Mercedes Viviana
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Universidad de San Martín de Porres
• Repositorio: Horizonte médico
• Lenguaje: español
• OAI Identifier: oai:horizontemedico.usmp.edu.pe:article/1309
• Enlace del recurso: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1309
• Nivel de acceso: acceso abierto
• Materia: Drug hypersensitivity syndrome; Carbamazepine; Exanthema; Eosinophilia; Síndrome de hipersensibilidad a medicamentos; Carbamazepina; Exantema; Eosinofilia

The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but highly lethal drug hypersensitivity reaction. Thus, it requires an early diagnosis and timely management. We present the case of a 32-year-old female patient with a diagnosis of epilepsy and organic schizophreniform disorder, secondary to viral encephalitis, who wastreated with multiple drugs. Three weeks after the addition of extended-release carbamazepine to her usual therapy, the patient presented a diffuse welt-type skin rash, facial edema, fever, lymphadenopathy, leukocytosis with eosinophilia and elevated transaminases. Carbamazepine administration was discontinued, antihistamines and glucocorticoids were administered orally, and the patient showed a remarkable improvement.