Differences between the Framingham and D:A:D risk models for cardiovascular risk assessment in HIV-positive patients on antiretroviral therapy: an experience in a Colombian Caribbean population

• Autores: Pinilla Sogamoso, Jorge Luis, Viloria Madrid, Johan Alfonso, Lozada Martinez, Ivan David, Hernández Anaya, Oscar Daniel, Cardenas Castañeda, Felipe Andrés, Llamas Nieves, Andrés Elías, Bolaño Romero, María Paz, Picón Jaimes, Yelson Alejandro
• Formato: artículo
• Fecha de Publicación: 2021
• Institución: Universidad de San Martín de Porres
• Repositorio: Horizonte médico
• Lenguaje: español
• OAI Identifier: oai:horizontemedico.usmp.edu.pe:article/1671
• Enlace del recurso: https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1671
• Nivel de acceso: acceso abierto
• Materia: HIV infections; Cardiovascular models; Cardiovascular risk; Highly active antiretroviral therapy; Caribbean región; Infecciones por VIH; Modelos cardiovasculares; Riesgo cardiovascular; Terapia antirretroviral altamente activa; Región del Caribe

Objective: To assess the five- and ten-year cardiovascular disease risk in HIV-positive patients on antiretroviral therapy, using the Framingham risk score and the Data collection on adverse effects of anti-HIV drugs (D:A:D) study. Materials and methods: An observational prospective cross-sectional study. HIV-positive patients on antiretroviral treatment from a referral center for HIV patients were included in the study between January 1 and April 30, 2019. A five- and ten-year cardiovascular risk assessment was performed using the Framingham risk score and the D:A:D study. Additionally, both risk models were compared through statistical models. Results: The study population consisted of 159 patients with a mean age of 48.90 years ± 9.90. The mean cardiovascular risk according to the five-year Framingham risk score was 2.70 % ± 2.80, the ten-year Framingham risk score was 6.10 % ± 5.70, the five-year D:A:D study was 3.50 % ± 4.10, the ten-year D:A:D study was 6.90 % ± 7.70, and the ten-year Framingham risk score recalculated for Colombia (multiplied by 0.75) was 4.50 % ± 4.20. Using a logistic regression model, it was determined that the ten-year D:A:D study provided the greatest number of variables significantly related to a high cardiovascular risk. Conclusions: The study showed a significant difference between the risk models. Both the five- and ten-year D:A:D study provided a better cardiovascular disease risk estimation than the five- and ten-year Framingham model.