Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals

Descripción del Articulo

Objective: To describe the presence and the concentration of neutralizing antibodies at serum of healthcare professionals inoculated with the Sinopharm anti-SARS-CoV2 vaccine. Materials and methods: Descriptive and transversal research. A total of 117 healthcare professionals inoculated with two dos...

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Detalles Bibliográficos
Autores: Pareja Cruz, Arturo, de León Delgado, Joel, Navarrete Mejía, Pedro Javier, Luque Espino, Julio César, Gonzáles Moscoso, Jesús Demóstenes
Formato: artículo
Fecha de Publicación:2021
Institución:Universidad de San Martín de Porres
Repositorio:Horizonte médico
Lenguaje:español
OAI Identifier:oai:horizontemedico.usmp.edu.pe:article/1543
Enlace del recurso:https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543
Nivel de acceso:acceso abierto
Materia:Anticuerpos neutralizantes
COVID-19
Inmunogenicidad
Vacunación
Personal de salud
Neutralizing antibodies
Coronavirus infections
Immunogenicity
Vaccination
Health personnel
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spelling Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionalsDetección de anticuerpos neutralizantes en profesionales de la salud vacunados contra el SARS-CoV-2Pareja Cruz, Arturo de León Delgado, Joel Navarrete Mejía, Pedro Javier Luque Espino, Julio César Gonzáles Moscoso, Jesús DemóstenesAnticuerpos neutralizantesCOVID-19InmunogenicidadVacunaciónPersonal de saludNeutralizing antibodiesCoronavirus infectionsImmunogenicityVaccinationHealth personnelObjective: To describe the presence and the concentration of neutralizing antibodies at serum of healthcare professionals inoculated with the Sinopharm anti-SARS-CoV2 vaccine. Materials and methods: Descriptive and transversal research. A total of 117 healthcare professionals inoculated with two doses of the Sinopharm vaccine having quantitative data of neutralizing antibodies at serum (detected by eCLIA) were included. Age, sex, neutralizing antibodies concentration and previous diagnostic of COVID-19 diseases were the variables. Results: A significant increase on neutralizing antibodies concentration were detected on pre- COVID-19 vaccinated persons regarding those vaccinated without previous diagnostic of the viral infection (p < 0,001). Conclusions: the study evidence that Sinopharm vaccine boost immunity against the new coronavirus on previously infected persons and suggest that a third dose of the vaccine could be relevant to boost the immune response.Objetivo: Determinar la presencia y concentración de los anticuerpos neutralizantes en el suero de individuos que recibieron la vacuna contra el SARS-CoV-2 desarrollada por la empresa Sinopharm. Materiales y métodos: Investigación descriptiva y transversal. En el estudio se incluyeron 117 profesionales de la salud inoculados con dos dosis de la vacuna Sinopharm, en quienes se había detectado la presencia de anticuerpos neutralizantes contra SARS-CoV-2 en el suero mediante la técnica de inmunoensayo de electroquimioluminiscencia (eCLIA). Las variables consideradas en el estudio fueron la edad, el sexo, la concentración de anticuerpos neutralizantes y el antecedente de haber tenido COVID-19. Resultados: Se evidenció el incremento significativo de la concentración de anticuerpos neutralizantes en las personas que recibieron la vacuna y tuvieron una infección previa por SARS-CoV-2 (p < 0,001) respecto a las que se vacunaron, pero no presentaron infección previa. Conclusiones: El estudio evidencia que la vacunación refuerza la inmunidad contra el nuevo coronavirus en los pacientes con diagnóstico previo de COVID-19 y sugiere la relevancia de la aplicación de una tercera dosis de esta vacuna.Universidad de San Martín de Porres. Facultad de Medicina Humana2021-07-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdftext/htmltext/xmlhttps://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/154310.24265/horizmed.2021.v21n3.02Horizonte Médico (Lima); Vol. 21 No. 3 (2021): July - September; e1543Horizonte Médico (Lima); Vol. 21 Núm. 3 (2021): Julio - Setiembre; e1543Horizonte Médico (Lima); v. 21 n. 3 (2021): Julio - Setiembre; e15432227-35301727-558Xreponame:Horizonte médicoinstname:Universidad de San Martín de Porresinstacron:USMPspahttps://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543/964https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543/998https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543/1000Derechos de autor 2021 Horizonte Médico (Lima)https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessoai:horizontemedico.usmp.edu.pe:article/15432022-06-22T17:15:31Z
dc.title.none.fl_str_mv Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
Detección de anticuerpos neutralizantes en profesionales de la salud vacunados contra el SARS-CoV-2
title Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
spellingShingle Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
Pareja Cruz, Arturo
Anticuerpos neutralizantes
COVID-19
Inmunogenicidad
Vacunación
Personal de salud
Neutralizing antibodies
Coronavirus infections
Immunogenicity
Vaccination
Health personnel
title_short Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
title_full Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
title_fullStr Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
title_full_unstemmed Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
title_sort Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
dc.creator.none.fl_str_mv Pareja Cruz, Arturo
de León Delgado, Joel
Navarrete Mejía, Pedro Javier
Luque Espino, Julio César
Gonzáles Moscoso, Jesús Demóstenes
author Pareja Cruz, Arturo
author_facet Pareja Cruz, Arturo
de León Delgado, Joel
Navarrete Mejía, Pedro Javier
Luque Espino, Julio César
Gonzáles Moscoso, Jesús Demóstenes
author_role author
author2 de León Delgado, Joel
Navarrete Mejía, Pedro Javier
Luque Espino, Julio César
Gonzáles Moscoso, Jesús Demóstenes
author2_role author
author
author
author
dc.subject.none.fl_str_mv Anticuerpos neutralizantes
COVID-19
Inmunogenicidad
Vacunación
Personal de salud
Neutralizing antibodies
Coronavirus infections
Immunogenicity
Vaccination
Health personnel
topic Anticuerpos neutralizantes
COVID-19
Inmunogenicidad
Vacunación
Personal de salud
Neutralizing antibodies
Coronavirus infections
Immunogenicity
Vaccination
Health personnel
description Objective: To describe the presence and the concentration of neutralizing antibodies at serum of healthcare professionals inoculated with the Sinopharm anti-SARS-CoV2 vaccine. Materials and methods: Descriptive and transversal research. A total of 117 healthcare professionals inoculated with two doses of the Sinopharm vaccine having quantitative data of neutralizing antibodies at serum (detected by eCLIA) were included. Age, sex, neutralizing antibodies concentration and previous diagnostic of COVID-19 diseases were the variables. Results: A significant increase on neutralizing antibodies concentration were detected on pre- COVID-19 vaccinated persons regarding those vaccinated without previous diagnostic of the viral infection (p < 0,001). Conclusions: the study evidence that Sinopharm vaccine boost immunity against the new coronavirus on previously infected persons and suggest that a third dose of the vaccine could be relevant to boost the immune response.
publishDate 2021
dc.date.none.fl_str_mv 2021-07-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543
10.24265/horizmed.2021.v21n3.02
url https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543
identifier_str_mv 10.24265/horizmed.2021.v21n3.02
dc.language.none.fl_str_mv spa
language spa
dc.relation.none.fl_str_mv https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543/964
https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543/998
https://www.horizontemedico.usmp.edu.pe/index.php/horizontemed/article/view/1543/1000
dc.rights.none.fl_str_mv Derechos de autor 2021 Horizonte Médico (Lima)
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Derechos de autor 2021 Horizonte Médico (Lima)
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
text/html
text/xml
dc.publisher.none.fl_str_mv Universidad de San Martín de Porres. Facultad de Medicina Humana
publisher.none.fl_str_mv Universidad de San Martín de Porres. Facultad de Medicina Humana
dc.source.none.fl_str_mv Horizonte Médico (Lima); Vol. 21 No. 3 (2021): July - September; e1543
Horizonte Médico (Lima); Vol. 21 Núm. 3 (2021): Julio - Setiembre; e1543
Horizonte Médico (Lima); v. 21 n. 3 (2021): Julio - Setiembre; e1543
2227-3530
1727-558X
reponame:Horizonte médico
instname:Universidad de San Martín de Porres
instacron:USMP
instname_str Universidad de San Martín de Porres
instacron_str USMP
institution USMP
reponame_str Horizonte médico
collection Horizonte médico
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 13.425424
Detection of neutralizing antibodies on anti-SARS-CoV2 vaccinated healthcare professionals
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