HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron
Descripción del Articulo
Of cellular adaptation to hypoxia and are strongly expressed under conditions of regional and systemic hypoxia. HIF-2 seems to be more related to the secretion of mature EPO interstitial fibroblasts. Upon a state of systemic hypoxia, such as anemia, induces the formation of HIF-1 and 2. Renal tubula...
| Autor: | |
|---|---|
| Formato: | artículo |
| Fecha de Publicación: | 2011 |
| Institución: | Colegio Médico del Perú |
| Repositorio: | Acta Médica Peruana |
| Lenguaje: | español |
| OAI Identifier: | oai:ojs.pkp.sfu.ca:article/1109 |
| Enlace del recurso: | https://amp.cmp.org.pe/index.php/AMP/article/view/1109 |
| Nivel de acceso: | acceso abierto |
| Materia: | Iron anoxia hypoxia-inducible factor 1 |
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HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular ironEl factor HIF-1 inducido por la hipoxia y la sensibilidad al oxígeno. Rol del hierro intracelularWagner Grau, Patrick Ironanoxiahypoxia-inducible factor 1Of cellular adaptation to hypoxia and are strongly expressed under conditions of regional and systemic hypoxia. HIF-2 seems to be more related to the secretion of mature EPO interstitial fibroblasts. Upon a state of systemic hypoxia, such as anemia, induces the formation of HIF-1 and 2. Renal tubular cells express only HIF-1. The HIF2 found in glomerular cells, peritubular endothelial cells and interstitial fibroblasts. HIF-1 and HIF-2 seem to play complementary roles rather than redundant roles in vivo. Both factors have been studied in various kidney diseases: in acute kidney injury, in chronic kidney disease, in polycystic kidney disease and kidney cancer. Various chemical substances, including iron, can inhibit the HIF - prolyl - hydroxylas e (PHD) thus avoiding the degradation of HIF molecules 1 and 2 .Los dos factores inducibles por la hipoxia, HIF-1 y HIF-2 son los principales mediadores de la adaptación celular a la hipoxia y se hallan fuertemente expresados, en condiciones de hipoxia tanto regional como sistémica. HIF-2 parece estar más en relación con la secreción de EPO por los fibroblastos maduros intersticiales. Al producirse un estado de hipoxia sistémica, como es el caso de la anemia, se induce la formación de HIF-1 y 2. Las células tubulares renales expresan sólo HIF-1. El HIF2 se encuentra en las células glomerulares, las células endoteliales peritubulares y los fibroblastos intersticiales. HIF-1 y HIF-2 parecen ejercer roles complementarios más que papeles redundantes in vivo. Ambos factores han sido estudiados en diversas patologías renales: en lesiones renales agudas, en patología crónica del riñón, en la poliquistosis renal y en el cáncer de riñón. Diversas sustancias químicas, incluyendo el hierro, son capaces de inhibir a las HIF – prolil – hidroxilasas (PHD) evitar así la degradación de las moléculas de HIF 1 y 2.Colegio Médico del Perú2011-09-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://amp.cmp.org.pe/index.php/AMP/article/view/1109ACTA MEDICA PERUANA; Vol 28 No 3 (2011); 163-168ACTA MEDICA PERUANA; Vol. 28 Núm. 3 (2011); 163-1681728-59171018-8800reponame:Acta Médica Peruanainstname:Colegio Médico del Perúinstacron:CMPspahttps://amp.cmp.org.pe/index.php/AMP/article/view/1109/587Copyright (c) 2020 ACTA MEDICA PERUANAinfo:eu-repo/semantics/openAccessoai:ojs.pkp.sfu.ca:article/11092023-07-06T05:59:04Z |
| dc.title.none.fl_str_mv |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron El factor HIF-1 inducido por la hipoxia y la sensibilidad al oxígeno. Rol del hierro intracelular |
| title |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron |
| spellingShingle |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron Wagner Grau, Patrick Iron anoxia hypoxia-inducible factor 1 |
| title_short |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron |
| title_full |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron |
| title_fullStr |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron |
| title_full_unstemmed |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron |
| title_sort |
HIF-1 factor induced by hypoxia and oxygen sensitivity. Role of intracellular iron |
| dc.creator.none.fl_str_mv |
Wagner Grau, Patrick |
| author |
Wagner Grau, Patrick |
| author_facet |
Wagner Grau, Patrick |
| author_role |
author |
| dc.subject.none.fl_str_mv |
Iron anoxia hypoxia-inducible factor 1 |
| topic |
Iron anoxia hypoxia-inducible factor 1 |
| description |
Of cellular adaptation to hypoxia and are strongly expressed under conditions of regional and systemic hypoxia. HIF-2 seems to be more related to the secretion of mature EPO interstitial fibroblasts. Upon a state of systemic hypoxia, such as anemia, induces the formation of HIF-1 and 2. Renal tubular cells express only HIF-1. The HIF2 found in glomerular cells, peritubular endothelial cells and interstitial fibroblasts. HIF-1 and HIF-2 seem to play complementary roles rather than redundant roles in vivo. Both factors have been studied in various kidney diseases: in acute kidney injury, in chronic kidney disease, in polycystic kidney disease and kidney cancer. Various chemical substances, including iron, can inhibit the HIF - prolyl - hydroxylas e (PHD) thus avoiding the degradation of HIF molecules 1 and 2 . |
| publishDate |
2011 |
| dc.date.none.fl_str_mv |
2011-09-28 |
| dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.none.fl_str_mv |
https://amp.cmp.org.pe/index.php/AMP/article/view/1109 |
| url |
https://amp.cmp.org.pe/index.php/AMP/article/view/1109 |
| dc.language.none.fl_str_mv |
spa |
| language |
spa |
| dc.relation.none.fl_str_mv |
https://amp.cmp.org.pe/index.php/AMP/article/view/1109/587 |
| dc.rights.none.fl_str_mv |
Copyright (c) 2020 ACTA MEDICA PERUANA info:eu-repo/semantics/openAccess |
| rights_invalid_str_mv |
Copyright (c) 2020 ACTA MEDICA PERUANA |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
application/pdf |
| dc.publisher.none.fl_str_mv |
Colegio Médico del Perú |
| publisher.none.fl_str_mv |
Colegio Médico del Perú |
| dc.source.none.fl_str_mv |
ACTA MEDICA PERUANA; Vol 28 No 3 (2011); 163-168 ACTA MEDICA PERUANA; Vol. 28 Núm. 3 (2011); 163-168 1728-5917 1018-8800 reponame:Acta Médica Peruana instname:Colegio Médico del Perú instacron:CMP |
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Colegio Médico del Perú |
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CMP |
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CMP |
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Acta Médica Peruana |
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Acta Médica Peruana |
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1816075104012992512 |
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13.958958 |
Nota importante:
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
La información contenida en este registro es de entera responsabilidad de la institución que gestiona el repositorio institucional donde esta contenido este documento o set de datos. El CONCYTEC no se hace responsable por los contenidos (publicaciones y/o datos) accesibles a través del Repositorio Nacional Digital de Ciencia, Tecnología e Innovación de Acceso Abierto (ALICIA).
