Efficacy of sodium valproate in the prophylactic treatment of migraine

• Autores: Lizárraga Luyo, Juan Fernando, Jara Pinto, Pilar Milagros, Unzueta Rozas, Leónidas E.
• Formato: artículo
• Fecha de Publicación: 2012
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:amp.cmp.org.pe:article/1137
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/1137
• Nivel de acceso: acceso abierto
• Materia: Transtorno migrañoso; dolor; ácido valproico; eficacia; valproato de sodio Migraine Disorders; pain; valproic acid; efficacy

Introduction: migraine is a chronic recurrent pain syndrome accompanied by neurological features. Objectives: evaluate the efficacy of sodium valproate in the migraine prophylactic, measuring pain intensity and frequency. Material and Methods: prospective, longitudinal, experiemental and randomized in 30 patients, each patient received in the 1st week 1 table/day of 500 mg orally and 2 table/day of 500 mg for the next 7 weeks Results: 97% reported decreased pain intensity. 97% were in category 3 of frequency of migraine attacks per month 0. during the 1 st month of treatment, it was reduced to 0% and remained during the 2nd month. Conclusions: prophylactic treatment of migraine with sodium valproate causes a decrease in pain intensity and frequency.