Adulto mayor con triple neoplasia maligna primaria sincrónica: reporte de caso y revisión de la literatura

• Autores: Yan-Quiroz, Edgar Fermín, Agreda-Castro, Folker, Vásquez-Jaico, Erick Ricardo, García de Lama, Marcelo, Alcántara-Espejo, Carlos, Tenazoa-Villalobos, José Richard
• Formato: artículo
• Fecha de Publicación: 2025
• Institución: Colegio Médico del Perú
• Repositorio: Acta Médica Peruana
• Lenguaje: español
• OAI Identifier: oai:amp.cmp.org.pe:article/3592
• Enlace del recurso: https://amp.cmp.org.pe/index.php/AMP/article/view/3592
• Nivel de acceso: acceso abierto
• Materia: Neoplasias Primarias Múltiples; Neoplasias Primarias Secundarias; Cáncer Papilar Tiroideo; Neoplasias del Colon; Carcinoma de Células Renales; Neoplasms, Multiple Primary; Neoplasms, Second Primary; Thyroid Cancer, Papillary; Colonic Neoplasms; Carcinoma, Renal Cell

Patients with a malignancy are at high risk of suffering from not only a second but also a third synchronous primary malignancy. This singular event, characterized by the association of three or more malignancies simultaneously, is infrequent, with a frequency ranging from 0.04% to 0.81%, and it predominantly affects women. The etiology is based on a strong association with genetic instability (BRAF, RAS, etc.), which interacts and leads to unfavorable outcomes in the prognosis of survival. We present the case of a 77-year-old man who underwent initial surgery for papillary thyroid carcinoma, colon adenocarcinoma, and clear cell renal carcinoma simultaneously, who was diagnosed and managed with initial surgery. After tolerating three interventions to date, the patient is being monitored without evidence of recurrence and is evolving favorably, without alterations in lifestyle, which suggests that surgery has high potential in the management of these neoplasms.