The association of intolerance to non-steroidal anti-inflammatory drugs, bronchial asthma and nasal polyps: Clinical aspects and treatment strategies in Poland

• Autor: Lisiecka, Maria Zofia
• Formato: artículo
• Fecha de Publicación: 2025
• Institución: Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Repositorio: Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Lenguaje: español
• OAI Identifier: oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/2829
• Enlace del recurso: https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/2829
• Nivel de acceso: acceso abierto
• Materia: Alergia; Desensibilización; Marcadores diagnósticos; Farmacoterapia; Hipersensibilidad; Allergy; Desensitization; Diagnostic markers; Pharmacotherapy; Hypersensitivity

Introduction: The aim of this study was to investigate the correlation between intolerance to non-steroidal anti-inflammatory drugs (NSAIDs), bronchial asthma, and nasal polyps, and to develop an effective treatment strategy for patients suffering from these conditions simultaneously. Material and Methods: The study was conducted across several clinical centres and included 200 patients diagnosed with bronchial asthma and nasal polyps, as well as intolerance to NSAIDs. Data were collected on the clinical manifestations of the pathology, including disease symptoms, frequency, and severity of exacerbations, along with their allergic history and tolerance to various drugs. Additionally, laboratory tests were performed, including blood tests to determine eosinophil levels, immunoglobulin E, and other inflammatory markers. Results: Based on the collected data, individualized treatment regimens were developed, combining pharmacotherapy and methods of desensitization to NSAIDs. Pharmacotherapy included the use of inhaled corticosteroids to reduce airway inflammation, antihistamines to control allergic symptoms, and monoclonal antibodies to modify the immune response. Desensitization methods involved the gradual introduction of NSAIDs under strict medical supervision, which helped to increase tolerance to these drugs. Conclusions: The results showed that this comprehensive and individualized approach significantly improved patients’ quality of life, reducing the frequency and severity of exacerbations, improving lung function, and overall well-being. This study emphasizes the importance of a comprehensive approach to the diagnosis and treatment of patients with intolerance to NSAIDs, bronchial asthma, and nasal polyps, and the need for further research in this area.