Bilinear Acute Monocytic Leukemia/B BCR ABL positive. presentation of a case

• Autores: Tello Vera , Stalin, Carpio Vásquez , Wendy del Carmen, Tirado Cruz, Carlos
• Formato: artículo
• Fecha de Publicación: 2023
• Institución: Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Repositorio: Revista del Cuerpo Médico Hospital Nacional Almanzor Aguinaga Asenjo
• Lenguaje: español
• OAI Identifier: oai:cmhnaaa_ojs_cmhnaaa.cmhnaaa.org.pe:article/1820
• Enlace del recurso: https://cmhnaaa.org.pe/ojs/index.php/rcmhnaaa/article/view/1820
• Nivel de acceso: acceso abierto
• Materia: Leucemia de Células B; Leucemia Mieloide Aguda; Leucemia-Linfoma Linfoblástico de Células Precursoras B; Leucemia Monocítica Aguda; Leukemia, B-Cell; Leukemia, Myeloid, Acute; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Monocytic, Acute

Background: Leukemias with an ambiguous phenotype are classified as undifferentiated leukemias and mixed phenotypes, these in turn can be divided into bilinear or biphenotypic and are usually associated with a poor prognosis, especially if they are accompanied by aggressive translocations such as the Philadelphia chromosome. Case report: We present the case of an elderly adult patient who presented acute bilinear leukemia with the presence of a population of monoblastic lineage precursors and another, B lymphoid, evaluated by flow cytometry studies, who also presented the BCR-ABL transcript. , detected by real-time PCR studies. The patient had a poor evolution and died 11 days after her diagnosis. Conclusion: Mixed phenotype leukemias have a poor prognosis and require early diagnosis by flow cytometry and molecular biology to provide timely treatment.