ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer

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The ALK receptor tyrosine kinase (ALK) gene encodes a transmembrane protein rearranged in 2-7% of non-small cell lung cancer (NSCLC) cases. This gene has become the second most studied therapeutic target after EGFR due to the implied therapeutic opportunities. While the diagnostic of ALK rearrangeme...

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Detalles Bibliográficos
Autores: Rosas, G, Ruiz, Rossana, Araujo, JM, Pinto, JA, Mas L, Luis
Formato: artículo
Fecha de Publicación:2019
Institución:Instituto Nacional de Enfermedades Neoplásicas
Repositorio:INEN-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.inen.sld.pe:20.500.14703/131
Enlace del recurso:https: //doi.org/10.1016/j.critrevonc.2019.02.006
https://hdl.handle.net/20.500.14703/131
Nivel de acceso:acceso abierto
Materia:ALK
Diagnostic tests
Non-small cell lung cancer
Tyrosine-kinase inhibitors
https://purl.org/pe-repo/ocde/ford#3.02.21
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spelling PublicationRosas, GRuiz, RossanaAraujo, JMPinto, JAMas L, Luis2024-07-01T16:28:55Z2024-07-01T16:28:55Z2019https: //doi.org/10.1016/j.critrevonc.2019.02.006https://hdl.handle.net/20.500.14703/131Crit Rev Oncol HematolThe ALK receptor tyrosine kinase (ALK) gene encodes a transmembrane protein rearranged in 2-7% of non-small cell lung cancer (NSCLC) cases. This gene has become the second most studied therapeutic target after EGFR due to the implied therapeutic opportunities. While the diagnostic of ALK rearrangements is well established, small molecules targeting ALK are in constant evolution because tumor cells eventually will develop mechanisms of resistance. In this review we describe the biology of the ALK gene, alterations, epidemiology, diagnostic tests as well as strategies of treatment.application/pdfengElsevier Ireland LtdIEinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/ALKDiagnostic testsNon-small cell lung cancerTyrosine-kinase inhibitorshttps://purl.org/pe-repo/ocde/ford#3.02.21ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancerinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:INEN-Institucionalinstname:Instituto Nacional de Enfermedades Neoplásicasinstacron:INENORIGINALG Rosas 2019.pdfapplication/pdf322009https://repositorio.inen.sld.pe/backend/api/core/bitstreams/4fa4ae8c-f6dc-476b-9479-b7f9548d12ac/download9601f485b7944d6f0c8ca349bd023199MD51trueAnonymousREADTEXTG Rosas 2019.pdf.txtWritten by FormatFilter org.dspace.app.mediafilter.TikaTextExtractionFilter on 2025-03-29T20:41:31Z (GMT).Extracted texttext/plain52486https://repositorio.inen.sld.pe/backend/api/core/bitstreams/ca268805-b60f-4b35-9ab6-09f17dffb39c/downloaded7f464a843e42cda0bd929454720d55MD54falseAnonymousREADTHUMBNAILG Rosas 2019.pdf.jpgWritten by FormatFilter org.dspace.app.mediafilter.PDFBoxThumbnail on 2025-03-29T20:41:31Z (GMT).Generated Thumbnailimage/jpeg25337https://repositorio.inen.sld.pe/backend/api/core/bitstreams/e6fc165c-871d-4cb9-b394-f266c01c81e6/download76a3a4d2292c6d2f3dba5d206a60a8daMD55falseAnonymousREAD20.500.14703/131oai:repositorio.inen.sld.pe:20.500.14703/1312026-02-14T01:27:21.735Zhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessopen.accesshttps://repositorio.inen.sld.peRepositorio del Instituto Nacional de Enfermedades Neoplásicasrepositorio@inen.sld.pe
dc.title.none.fl_str_mv ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
title ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
spellingShingle ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
Rosas, G
ALK
Diagnostic tests
Non-small cell lung cancer
Tyrosine-kinase inhibitors
https://purl.org/pe-repo/ocde/ford#3.02.21
title_short ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
title_full ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
title_fullStr ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
title_full_unstemmed ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
title_sort ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
author Rosas, G
author_facet Rosas, G
Ruiz, Rossana
Araujo, JM
Pinto, JA
Mas L, Luis
author_role author
author2 Ruiz, Rossana
Araujo, JM
Pinto, JA
Mas L, Luis
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Rosas, G
Ruiz, Rossana
Araujo, JM
Pinto, JA
Mas L, Luis
dc.subject.none.fl_str_mv ALK
Diagnostic tests
Non-small cell lung cancer
Tyrosine-kinase inhibitors
topic ALK
Diagnostic tests
Non-small cell lung cancer
Tyrosine-kinase inhibitors
https://purl.org/pe-repo/ocde/ford#3.02.21
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.21
description The ALK receptor tyrosine kinase (ALK) gene encodes a transmembrane protein rearranged in 2-7% of non-small cell lung cancer (NSCLC) cases. This gene has become the second most studied therapeutic target after EGFR due to the implied therapeutic opportunities. While the diagnostic of ALK rearrangements is well established, small molecules targeting ALK are in constant evolution because tumor cells eventually will develop mechanisms of resistance. In this review we describe the biology of the ALK gene, alterations, epidemiology, diagnostic tests as well as strategies of treatment.
publishDate 2019
dc.date.accessioned.none.fl_str_mv 2024-07-01T16:28:55Z
dc.date.available.none.fl_str_mv 2024-07-01T16:28:55Z
dc.date.issued.fl_str_mv 2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.doi.none.fl_str_mv https: //doi.org/10.1016/j.critrevonc.2019.02.006
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.14703/131
dc.identifier.journal.none.fl_str_mv Crit Rev Oncol Hematol
url https: //doi.org/10.1016/j.critrevonc.2019.02.006
https://hdl.handle.net/20.500.14703/131
identifier_str_mv Crit Rev Oncol Hematol
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier Ireland Ltd
dc.publisher.country.none.fl_str_mv IE
publisher.none.fl_str_mv Elsevier Ireland Ltd
dc.source.none.fl_str_mv reponame:INEN-Institucional
instname:Instituto Nacional de Enfermedades Neoplásicas
instacron:INEN
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ALK rearrangements: Biology, detection and opportunities of therapy in non-small cell lung cancer
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