Prospective Validation of a 21-Gene Expression Assay in Breast Cancer

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Prior studies with the use of a prospective–retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence...

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Detalles Bibliográficos
Autores: Sparano, JA, Gray, RJ, Makower, DF, Pritchard, KI, Albain, KS, Hayes, DF, Geyer, CE Jr, Dees, EC, Perez, EA, Olson, JA Jr, Zujewski, J, Lively, T, Badve, SS, Saphner, TJ, Wagner, LI, Whelan, TJ, Ellis, MJ, Paik, S, Wood, WC, Ravdin, P, Keane, MM, Gomez, HL, Reddy, PS, Goggins, TF, Mayer, IA, Brufsky, AM, Toppmeyer, DL, Kaklamani, VG, Atkins, JN, Berenberg, JL, Sledge, GW
Formato: artículo
Fecha de Publicación:2015
Institución:Instituto Nacional de Enfermedades Neoplásicas
Repositorio:INEN-Institucional
Lenguaje:inglés
OAI Identifier:oai:repositorio.inen.sld.pe:20.500.14703/122
Enlace del recurso:https://hdl.handle.net/20.500.14703/122
Nivel de acceso:acceso abierto
Materia:21-Gene Expression Assay
Breast Cancer
https://purl.org/pe-repo/ocde/ford#3.02.21
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spelling PublicationSparano, JAGray, RJMakower, DFPritchard, KIAlbain, KSHayes, DFGeyer, CE JrDees, ECPerez, EAOlson, JA JrZujewski, JLively, TBadve, SSSaphner, TJWagner, LIWhelan, TJEllis, MJPaik, SWood, WCRavdin, PKeane, MMGomez, HLReddy, PSGoggins, TFMayer, IABrufsky, AMToppmeyer, DLKaklamani, VGAtkins, JNBerenberg, JLSledge, GW2024-07-01T16:28:52Z2024-07-01T16:28:52Z201510.1056/NEJMoa1510764https://hdl.handle.net/20.500.14703/122N Engl J MedPrior studies with the use of a prospective–retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker.application/pdfengMassachussetts Medical SocietyUSinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/21-Gene Expression AssayBreast Cancerhttps://purl.org/pe-repo/ocde/ford#3.02.21Prospective Validation of a 21-Gene Expression Assay in Breast Cancerinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionreponame:INEN-Institucionalinstname:Instituto Nacional de Enfermedades Neoplásicasinstacron:INENORIGINALSparano 2015.pdfapplication/pdf443582https://repositorio.inen.sld.pe/backend/api/core/bitstreams/da1db45d-ea12-4db5-bcc8-140a131e771c/downloade70c36e25b8239c12e50232ce11b9fd7MD51trueAnonymousREADTEXTSparano 2015.pdf.txtWritten by FormatFilter org.dspace.app.mediafilter.TikaTextExtractionFilter on 2025-03-29T20:42:05Z (GMT).Extracted texttext/plain53120https://repositorio.inen.sld.pe/backend/api/core/bitstreams/f1d2698c-2305-4454-ae1a-514f2bfc0d3f/download8e6d3770b939679874292a94375c7314MD54falseAnonymousREADTHUMBNAILSparano 2015.pdf.jpgWritten by FormatFilter org.dspace.app.mediafilter.PDFBoxThumbnail on 2025-03-29T20:42:05Z (GMT).Generated Thumbnailimage/jpeg43937https://repositorio.inen.sld.pe/backend/api/core/bitstreams/26889bc3-3bb8-4a29-aff4-1e13286a411e/downloada3077f7c77e8cdd7e9bf2fc9cb7c8f30MD55falseAnonymousREAD20.500.14703/122oai:repositorio.inen.sld.pe:20.500.14703/1222026-02-17T16:48:50.589Zhttps://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessopen.accesshttps://repositorio.inen.sld.peRepositorio del Instituto Nacional de Enfermedades Neoplásicasrepositorio@inen.sld.pe
dc.title.none.fl_str_mv Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
title Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
spellingShingle Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
Sparano, JA
21-Gene Expression Assay
Breast Cancer
https://purl.org/pe-repo/ocde/ford#3.02.21
title_short Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
title_full Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
title_fullStr Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
title_full_unstemmed Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
title_sort Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
author Sparano, JA
author_facet Sparano, JA
Gray, RJ
Makower, DF
Pritchard, KI
Albain, KS
Hayes, DF
Geyer, CE Jr
Dees, EC
Perez, EA
Olson, JA Jr
Zujewski, J
Lively, T
Badve, SS
Saphner, TJ
Wagner, LI
Whelan, TJ
Ellis, MJ
Paik, S
Wood, WC
Ravdin, P
Keane, MM
Gomez, HL
Reddy, PS
Goggins, TF
Mayer, IA
Brufsky, AM
Toppmeyer, DL
Kaklamani, VG
Atkins, JN
Berenberg, JL
Sledge, GW
author_role author
author2 Gray, RJ
Makower, DF
Pritchard, KI
Albain, KS
Hayes, DF
Geyer, CE Jr
Dees, EC
Perez, EA
Olson, JA Jr
Zujewski, J
Lively, T
Badve, SS
Saphner, TJ
Wagner, LI
Whelan, TJ
Ellis, MJ
Paik, S
Wood, WC
Ravdin, P
Keane, MM
Gomez, HL
Reddy, PS
Goggins, TF
Mayer, IA
Brufsky, AM
Toppmeyer, DL
Kaklamani, VG
Atkins, JN
Berenberg, JL
Sledge, GW
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sparano, JA
Gray, RJ
Makower, DF
Pritchard, KI
Albain, KS
Hayes, DF
Geyer, CE Jr
Dees, EC
Perez, EA
Olson, JA Jr
Zujewski, J
Lively, T
Badve, SS
Saphner, TJ
Wagner, LI
Whelan, TJ
Ellis, MJ
Paik, S
Wood, WC
Ravdin, P
Keane, MM
Gomez, HL
Reddy, PS
Goggins, TF
Mayer, IA
Brufsky, AM
Toppmeyer, DL
Kaklamani, VG
Atkins, JN
Berenberg, JL
Sledge, GW
dc.subject.none.fl_str_mv 21-Gene Expression Assay
Breast Cancer
topic 21-Gene Expression Assay
Breast Cancer
https://purl.org/pe-repo/ocde/ford#3.02.21
dc.subject.ocde.none.fl_str_mv https://purl.org/pe-repo/ocde/ford#3.02.21
description Prior studies with the use of a prospective–retrospective design including archival tumor samples have shown that gene-expression assays provide clinically useful prognostic information. However, a prospectively conducted study in a uniformly treated population provides the highest level of evidence supporting the clinical validity and usefulness of a biomarker.
publishDate 2015
dc.date.accessioned.none.fl_str_mv 2024-07-01T16:28:52Z
dc.date.available.none.fl_str_mv 2024-07-01T16:28:52Z
dc.date.issued.fl_str_mv 2015
dc.type.none.fl_str_mv info:eu-repo/semantics/article
dc.type.version.none.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.doi.none.fl_str_mv 10.1056/NEJMoa1510764
dc.identifier.uri.none.fl_str_mv https://hdl.handle.net/20.500.14703/122
dc.identifier.journal.none.fl_str_mv N Engl J Med
identifier_str_mv 10.1056/NEJMoa1510764
N Engl J Med
url https://hdl.handle.net/20.500.14703/122
dc.language.iso.none.fl_str_mv eng
language eng
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
dc.rights.uri.none.fl_str_mv https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0/
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Massachussetts Medical Society
dc.publisher.country.none.fl_str_mv US
publisher.none.fl_str_mv Massachussetts Medical Society
dc.source.none.fl_str_mv reponame:INEN-Institucional
instname:Instituto Nacional de Enfermedades Neoplásicas
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Prospective Validation of a 21-Gene Expression Assay in Breast Cancer
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