Early laboratory hematological parameters associated with COVID-19 mortality in an Amazonian population of Peru

• Autores: Iglesias Osores, Sebastián, Rafael Heredia, Arturo, Rojas Tello, Eric R., Ortiz Uribe, Washington A., Leveau Bartra, Walter R., Leveau Bartra, Orison A., Córdova Rojas, Lizbeth M., Colmenares Mayanga, Wagner, Failoc Rojas, Virgilio E.
• Formato: artículo
• Fecha de Publicación: 2023
• Institución: Seguro Social de Salud
• Repositorio: ESSALUD-Institucional
• Lenguaje: inglés
• OAI Identifier: oai:repositorio.essalud.gob.pe:20.500.12959/3730
• Enlace del recurso: https://hdl.handle.net/20.500.12959/3730; https://doi.org/10.35434/rcmhnaaa.2022.154.1529
• Nivel de acceso: acceso abierto
• Materia: Coronavirus-2019; 2019-nCoV; Covid-19; Novel Coronavirus (SARS-CoV-2/HCoV-19); SARS-CoV-2; Hallazgos de laboratorio; Pronóstico; Diagnóstico; Laboratory findings; Prognosis; Diagnosis; https://purl.org/pe-repo/ocde/ford#3.03.08; https://purl.org/pe-repo/ocde/ford#3.03.09

Background: COVID-19 has a significant impact on the hematopoietic system and hemostasis. Leukocytosis, lymphopenia, and thrombocytopenia are associated with increased severity and even death in COVID-19 cases. Objective: The aim is to examine the laboratory results of COVID-19 patients from a hospital in the Peruvian Amazon and their clinical prognosis. Material and Methods: An analytical cross-sectional study was carried out whose purpose was to identify the laboratory tests of patients with COVID-19 and mortality in a hospital in Ucayali, Peru during the period from March 13 to May 9, 2020, selecting a total of 127 with Covid-19. Mean and the standard deviation was described for age, leukocytes, neutrophils, platelets, RDW-SD; median and interquartile range for the variables lymphocyte, RN / L, fibrinogen, CRP, Ddimer, DHL, hematocrit, monocytes, eosinophils. Results: No differences were observed in this population regarding death and sex (OR: 1.31; 95% CI 0.92 to 1.87), however, it was observed that, for each one-year increase, the probability of death increased by 4% (PR: 1.04, 95% CI 1.03 to 1.05). The IRR (Incidence Risk Ratio) analysis for the numerical variables showed results strongly associated with hematological values such as Leukocytes (scaled by 2500 units) (IRR: 1.08, 95% CI 1.03 to 1.13), neutrophils (scaled by 2500 units) (IRR: 1.08; 95% CI 1.03 to 1.13), on the contrary, it is observed that the increase of 1000 units in lymphocytes, the probability of dying decreased by 48% (IRR: 0.52; 95% CI 0.38 to 071). Conclusions: Parameters such as leukocytes,neutrophils and D-dimer were statistically much higher in patients who died.